Cited 4 times in
Integrative analysis of multiple genomic data from intrahepatic cholangiocarcinoma organoids enables tumor subtyping
DC Field | Value | Language |
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dc.contributor.author | 박준용 | - |
dc.contributor.author | 송시영 | - |
dc.contributor.author | 이혜원 | - |
dc.contributor.author | 이희승 | - |
dc.contributor.author | 정다운 | - |
dc.contributor.author | 조중현 | - |
dc.contributor.author | 한대훈 | - |
dc.contributor.author | 임가람 | - |
dc.contributor.author | 김철훈 | - |
dc.date.accessioned | 2023-03-22T02:11:20Z | - |
dc.date.available | 2023-03-22T02:11:20Z | - |
dc.date.issued | 2023-01 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193543 | - |
dc.description.abstract | As genomic analysis technology has advanced, it has become possible to sub-classify intrahepatic cholangiocarcinoma (ICC) at the histological or molecular level. Here, we verify the recently suggested two subgroups of ICC in the organoids model, compare the characteristics between types. ICC patients are subclassified into small-duct (SD) and large-duct (LD) subtype according to histological characteristics. ICC organoids are established, and unsupervised principal component analysis clustering separates each type of ICC. Differential gene expression reveals enrichment on KRAS, TGFβ and ERBB2 signaling pathways in LD-type compared with SD-type (P < 0.05). Gene set enrichment analysis demonstrates that the cholangiocarcinoma class 2 signature, defined by Andersen et al., is enriched in the LD-type (enrichment Score = 2.19, P < 0.001). A protein-protein interaction network analysis identifies ZNF217 as a significant hub protein (odds ratio = 4.96, P = 0.0105). We perform prospective modeling of histological subtype using patient-derived organoids. Moreover, gene expression profiling of ICC organoids enables identification of type-specific targetable pathways. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Nature Pub. Group | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Bile Duct Neoplasms* / genetics | - |
dc.subject.MESH | Bile Duct Neoplasms* / pathology | - |
dc.subject.MESH | Bile Ducts, Intrahepatic | - |
dc.subject.MESH | Cholangiocarcinoma* / metabolism | - |
dc.subject.MESH | Genomics | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Prospective Studies | - |
dc.title | Integrative analysis of multiple genomic data from intrahepatic cholangiocarcinoma organoids enables tumor subtyping | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hee Seung Lee | - |
dc.contributor.googleauthor | Dai Hoon Han | - |
dc.contributor.googleauthor | Kyungjoo Cho | - |
dc.contributor.googleauthor | Soo Been Park | - |
dc.contributor.googleauthor | Chanyang Kim | - |
dc.contributor.googleauthor | Galam Leem | - |
dc.contributor.googleauthor | Dawoon E Jung | - |
dc.contributor.googleauthor | Soon Sung Kwon | - |
dc.contributor.googleauthor | Chul Hoon Kim | - |
dc.contributor.googleauthor | Jung Hyun Jo | - |
dc.contributor.googleauthor | Hye Won Lee | - |
dc.contributor.googleauthor | Si Young Song | - |
dc.contributor.googleauthor | Jun Yong Park | - |
dc.identifier.doi | 10.1038/s41467-023-35896-4 | - |
dc.contributor.localId | A01675 | - |
dc.contributor.localId | A02035 | - |
dc.contributor.localId | A03318 | - |
dc.contributor.localId | A03349 | - |
dc.contributor.localId | A03587 | - |
dc.contributor.localId | A03912 | - |
dc.contributor.localId | A04273 | - |
dc.relation.journalcode | J02293 | - |
dc.identifier.eissn | 2041-1723 | - |
dc.identifier.pmid | 36646721 | - |
dc.contributor.alternativeName | Park, Jun Yong | - |
dc.contributor.affiliatedAuthor | 박준용 | - |
dc.contributor.affiliatedAuthor | 송시영 | - |
dc.contributor.affiliatedAuthor | 이혜원 | - |
dc.contributor.affiliatedAuthor | 이희승 | - |
dc.contributor.affiliatedAuthor | 정다운 | - |
dc.contributor.affiliatedAuthor | 조중현 | - |
dc.contributor.affiliatedAuthor | 한대훈 | - |
dc.citation.volume | 14 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 237 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, Vol.14(1) : 237, 2023-01 | - |
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