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Serotype Distribution and Antimicrobial Resistance of Streptococcus pneumoniae Causing Invasive Pneumococcal Disease in Korea Between 2017 and 2019 After Introduction of the 13-Valent Pneumococcal Conjugate Vaccine

Authors
 Gyu Ri Kim  ;   Eun-Young Kim  ;   Si Hyun Kim   ;   Hae Kyung Lee   ;   Jaehyeon Lee   ;   Jong Hee Shin   ;   Young Ree Kim   ;   Sae Am Song  ;   Joseph Jeong   ;   Young Uh   ;   Yu Kyung Kim   ;   Dongeun Yong   ;   Hyun Soo Kim   ;   Sunjoo Kim   ;   Young Ah Kim  ;   Kyeong Seob Shin  ;   Seok Hoon Jeong   ;   Namhee Ryoo  ;   Jeong Hwan Shin 
Citation
 ANNALS OF LABORATORY MEDICINE, Vol.43(1) : 45-54, 2023-01 
Journal Title
ANNALS OF LABORATORY MEDICINE
ISSN
 2234-3806 
Issue Date
2023-01
MeSH
Anti-Bacterial Agents / pharmacology ; Drug Resistance, Bacterial ; Humans ; Microbial Sensitivity Tests ; Pneumococcal Infections* / epidemiology ; Pneumococcal Vaccines / pharmacology ; Serogroup ; Serotyping ; Streptococcus pneumoniae* / genetics ; Vaccines, Conjugate / pharmacology
Keywords
Bacterial ; Drug resistance ; Multiple drug resistance ; Mutlilocus sequence typing ; Serotyping ; Streptococcus pneumoniae
Abstract
Background: Streptococcus pneumoniae is a serious pathogen causing various infections in humans. We evaluated the serotype distribution and antimicrobial resistance of S. pneumoniae causing invasive pneumococcal disease (IPD) after introduction of pneumococcal conjugate vaccine (PCV)13 in Korea and investigated the epidemiological characteristics of multidrug-resistant (MDR) isolates.

Methods: S. pneumoniae isolates causing IPD were collected from 16 hospitals in Korea between 2017 and 2019. Serotyping was performed using modified sequential multiplex PCR and the Quellung reaction. Antimicrobial susceptibility tests were performed using the broth microdilution method. Multilocus sequence typing was performed on MDR isolates for epidemiological investigations.

Results: Among the 411 S. pneumoniae isolates analyzed, the most prevalent serotype was 3 (12.2%), followed by 10A (9.5%), 34 (7.3%), 19A (6.8%), 23A (6.3%), 22F (6.1%), 35B (5.8%), 11A (5.1%), and others (40.9%). The coverage rates of PCV7, PCV10, PCV13, and pneumococcal polysaccharide vaccine (PPSV)23 were 7.8%, 7.8%, 28.7%, and 59.4%, respectively. Resistance rates to penicillin, ceftriaxone, erythromycin, and levofloxacin were 13.1%, 9.2%, 80.3%, and 4.1%, respectively. MDR isolates accounted for 23.4% of all isolates. Serotypes 23A, 11A, 19A, and 15B accounted for the highest proportions of total isolates at 18.8%, 16.7%, 14.6%, and 8.3%, respectively. Sequence type (ST)166 (43.8%) and ST320 (12.5%) were common among MDR isolates.

Conclusions: Non-PCV13 serotypes are increasing among invasive S. pneumoniae strains causing IPD. Differences in antimicrobial resistance were found according to the specific serotype. Continuous monitoring of serotypes and antimicrobial resistance is necessary for the appropriate management of S. pneumoniae infections.
Files in This Item:
T202205772.pdf Download
DOI
10.3343/alm.2023.43.1.45
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Jeong, Seok Hoon(정석훈) ORCID logo https://orcid.org/0000-0001-9290-897X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/193506
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