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Clinical Significance of PIK3CA and ESR1 Mutations in Circulating Tumor DNA: Analysis from the MONARCH 2 Study of Abemaciclib plus Fulvestrant

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dc.contributor.author손주혁-
dc.date.accessioned2023-03-21T07:37:03Z-
dc.date.available2023-03-21T07:37:03Z-
dc.date.issued2022-04-
dc.identifier.issn1078-0432-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/193465-
dc.description.abstractPurpose: PIK3CA and ESR1 mutations have been implicated in resistance to endocrine therapy (ET) in HR+, HER2- advanced breast cancer (ABC). Inhibition of CDK4 and 6 has been hypothesized as a therapeutic strategy to overcome endocrine resistance in patients with PIK3CA- or ESR1-mutant breast cancers. The objective of this exploratory analysis was to assess efficacy of abemaciclib plus fulvestrant in patients with or without PIK3CA or ESR1 mutations in MONARCH 2. Patients and methods: MONARCH 2 was a global, randomized, double-blind phase III trial of abemaciclib plus fulvestrant in 669 women with HR+, HER2- ABC, which had progressed on ET. Patients were randomized 2:1 to receive abemaciclib plus fulvestrant or placebo plus fulvestrant. Exploratory analyses assessed progression-free survival (PFS) and overall survival (OS), and other endpoints, in patients with or without PIK3CA or ESR1 mutations detectable in baseline ctDNA. Results: From the MONARCH 2 population, 219 and 248 patient samples were successfully analyzed for either PIK3CA or ESR1 mutations, respectively. Abemaciclib plus fulvestrant improved PFS compared with placebo plus fulvestrant in both PIK3CA-wild-type (median 16.9 months vs. 12.3 months; HR, 0.51; 95% CI, 0.33-0.78) and PIK3CA-mutant subgroups (median 17.1 months vs. 5.7 months; HR, 0.53; 95% CI, 0.33-0.84), as well as both ESR1-wild-type (median 15.3 months vs. 11.2 months; HR, 0.44; 95% CI, 0.27-0.71) and ESR1-mutant subgroups (median 20.7 months vs. 13.1 months; HR, 0.54; 95% CI, 0.37-0.79). Additional endpoints, including OS, were also improved following treatment with abemaciclib plus fulvestrant regardless of PIK3CA or ESR1 mutation status. Conclusions: Abemaciclib plus fulvestrant was effective regardless of PIK3CA or ESR1 mutation status, with benefit in both PFS and OS, with a numerically greater improvement in median PFS relative to placebo plus fulvestrant for PIK3CA- or ESR1-mutant tumors compared with the respective wild-type subgroups, in women with HR+, HER2- ABC that had progressed on ET.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAmerican Association for Cancer Research-
dc.relation.isPartOfCLINICAL CANCER RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAminopyridines-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols / adverse effects-
dc.subject.MESHBenzimidazoles-
dc.subject.MESHBreast Neoplasms* / drug therapy-
dc.subject.MESHBreast Neoplasms* / genetics-
dc.subject.MESHBreast Neoplasms* / pathology-
dc.subject.MESHCirculating Tumor DNA* / genetics-
dc.subject.MESHClass I Phosphatidylinositol 3-Kinases / genetics-
dc.subject.MESHFemale-
dc.subject.MESHFulvestrant-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMutation-
dc.subject.MESHReceptor, ErbB-2 / genetics-
dc.subject.MESHReceptor, ErbB-2 / therapeutic use-
dc.titleClinical Significance of PIK3CA and ESR1 Mutations in Circulating Tumor DNA: Analysis from the MONARCH 2 Study of Abemaciclib plus Fulvestrant-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorSara M Tolaney-
dc.contributor.googleauthorMasakazu Toi-
dc.contributor.googleauthorPatrick Neven-
dc.contributor.googleauthorJoohyuk Sohn-
dc.contributor.googleauthorEva-Maria Grischke-
dc.contributor.googleauthorAntonio Llombart-Cussac-
dc.contributor.googleauthorHatem Soliman-
dc.contributor.googleauthorHong Wang-
dc.contributor.googleauthorSameera Wijayawardana-
dc.contributor.googleauthorValerie M Jansen-
dc.contributor.googleauthorLacey M Litchfield-
dc.contributor.googleauthorGeorge W Sledge-
dc.identifier.doi10.1158/1078-0432.CCR-21-3276-
dc.contributor.localIdA01995-
dc.relation.journalcodeJ00564-
dc.identifier.pmid35121623-
dc.identifier.urlhttps://aacrjournals.org/clincancerres/article/28/8/1500/694171/Clinical-Significance-of-PIK3CA-and-ESR1-Mutations-
dc.contributor.alternativeNameSohn, Joo Hyuk-
dc.contributor.affiliatedAuthor손주혁-
dc.citation.volume28-
dc.citation.number8-
dc.citation.startPage1500-
dc.citation.endPage1506-
dc.identifier.bibliographicCitationCLINICAL CANCER RESEARCH, Vol.28(8) : 1500-1506, 2022-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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