Cited 4 times in
House dust mite-induced Akt-ERK1/2-C/EBP beta pathway triggers CCL20-mediated inflammation and epithelial-mesenchymal transition for airway remodeling
DC Field | Value | Language |
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dc.contributor.author | 박중원 | - |
dc.contributor.author | 정숙인 | - |
dc.date.accessioned | 2023-03-21T07:29:57Z | - |
dc.date.available | 2023-03-21T07:29:57Z | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 0892-6638 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193405 | - |
dc.description.abstract | House dust mite (HDM) allergens cause inflammatory responses and chronic allergic diseases such as bronchial asthma and atopic dermatitis. Here, we investigate the mechanism by which HDM induces C-C chemokine ligand 20 (CCL20) expression to promote chronic inflammation and airway remodeling in an HDM-induced bronchial asthma mouse model. We showed that HDM increased CCL20 levels via the Akt-ERK1/2-C/EBPβ pathway. To investigate the role of CCL20 in chronic airway inflammation and remodeling, we made a mouse model of CCL20-induced bronchial asthma. Treatment of anti-CCL20Ab in this mouse model showed the reduced airway hyper-responsiveness and inflammatory cell infiltration into peribronchial region by neutralizing CCL20. In addition, CCL20 induced the Nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation through NLRP3 deubiquitination and transcriptional upregulation in BEAS-2B cells. As expected, anti-CCL20Ab markedly suppressed NLRP3 activation induced by CCL20. Moreover, HDM-induced CCL20 leads to epithelial-mesenchymal transition in the lung epithelium which appears to be an important regulator of airway remodeling in allergic asthma. We also found that anti-CCL20Ab attenuates airway inflammation and remodeling in an HDM-induced mouse model of bronchial asthma. Taken together, our results suggest that HDM-induced CCL20 is required for chronic inflammation that contributes airway remodeling in a mouse model of asthma. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | The Federation | - |
dc.relation.isPartOf | FASEB JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Airway Remodeling | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Asthma* / metabolism | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Epithelial-Mesenchymal Transition | - |
dc.subject.MESH | Inflammation / complications | - |
dc.subject.MESH | Ligands | - |
dc.subject.MESH | Lung / metabolism | - |
dc.subject.MESH | MAP Kinase Signaling System | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | NLR Family, Pyrin Domain-Containing 3 Protein / metabolism | - |
dc.subject.MESH | Proto-Oncogene Proteins c-akt / metabolism | - |
dc.subject.MESH | Pyroglyphidae* | - |
dc.title | House dust mite-induced Akt-ERK1/2-C/EBP beta pathway triggers CCL20-mediated inflammation and epithelial-mesenchymal transition for airway remodeling | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Shin-Young Park | - |
dc.contributor.googleauthor | Min-Jeong Kang | - |
dc.contributor.googleauthor | Nuri Jin | - |
dc.contributor.googleauthor | So Young Lee | - |
dc.contributor.googleauthor | Yun Young Lee | - |
dc.contributor.googleauthor | Sungsin Jo | - |
dc.contributor.googleauthor | Jeong Yun Eom | - |
dc.contributor.googleauthor | Heejae Han | - |
dc.contributor.googleauthor | Sook In Chung | - |
dc.contributor.googleauthor | Kiseok Jang | - |
dc.contributor.googleauthor | Tae-Hwan Kim | - |
dc.contributor.googleauthor | Jungwon Park | - |
dc.contributor.googleauthor | Joong-Soo Han | - |
dc.identifier.doi | 10.1096/fj.202200150RR | - |
dc.contributor.localId | A01681 | - |
dc.contributor.localId | A03640 | - |
dc.relation.journalcode | J00889 | - |
dc.identifier.eissn | 1530-6860 | - |
dc.identifier.pmid | 35916017 | - |
dc.subject.keyword | CCL20 (C-C chemokine ligand 20) | - |
dc.subject.keyword | NLRP3 (Nod-like receptor family pyrin domain containing 3 | - |
dc.subject.keyword | airway remodeling | - |
dc.subject.keyword | asthma | - |
dc.subject.keyword | house dust mites | - |
dc.contributor.alternativeName | Park, Jung Won | - |
dc.contributor.affiliatedAuthor | 박중원 | - |
dc.contributor.affiliatedAuthor | 정숙인 | - |
dc.citation.volume | 36 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | e22452 | - |
dc.identifier.bibliographicCitation | FASEB JOURNAL, Vol.36(9) : e22452, 2022-09 | - |
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