Cited 5 times in
Incremental prognostic value of triglyceride glucose index additional to coronary artery calcium score in asymptomatic low-risk population
DC Field | Value | Language |
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dc.contributor.author | 성지민 | - |
dc.contributor.author | 송신정 | - |
dc.contributor.author | 장혁재 | - |
dc.date.accessioned | 2023-03-21T07:26:55Z | - |
dc.date.available | 2023-03-21T07:26:55Z | - |
dc.date.issued | 2022-09 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193382 | - |
dc.description.abstract | Background: The triglyceride glucose (TyG) index has been suggested as a reliable surrogate marker of insulin resistance which is a substantial risk factor for atherosclerotic cardiovascular disease (ASCVD). Several recent studies have shown the relationship between the TyG index and cardiovascular disease; however, the role of the TyG index in coronary artery calcification (CAC) progression has not been extensively assessed especially in low-risk population. Methods: We enrolled 5775 Korean adults who had at least two CAC evaluations. We determined the TyG index using ln (fasting triglycerides [mg/dL] x fasting glucose [mg/dL]/2). The CAC progression was defined as either incident CAC in a CAC-free population at baseline or an increase of ≥ 2.5 units between the square roots of the baseline and follow-up coronary artery calcium scores (CACSs) of subjects with detectable CAC at baseline. Results: CAC progression was seen in 1,382 subjects (23.9%) during mean 3.5 years follow-up. Based on the TyG index, subjects were stratified into four groups. Follow-up CACS and incidence of CAC progression were markedly elevated with rising TyG index quartiles (group I [lowest]:17.6% vs. group II:22.2% vs. group III:24.6% vs. group IV [highest]: 31.3%, p < 0.001). In multivariate logistic regression analysis, the TyG index was independent predictor of CAC progression (odds ratio: 1.57; 95% confidence interval: 1.33 to 1.81; p < 0.001) especially in baseline CACS ≤ 100 group. Conclusion: The TyG index is an independent predictor of CAC progression in low-risk population. It adds incremental risk stratification over established factors including baseline CACS. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | CARDIOVASCULAR DIABETOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Biomarkers | - |
dc.subject.MESH | Blood Glucose | - |
dc.subject.MESH | Calcium | - |
dc.subject.MESH | Cardiovascular Diseases* | - |
dc.subject.MESH | Coronary Artery Disease* / diagnostic imaging | - |
dc.subject.MESH | Coronary Artery Disease* / epidemiology | - |
dc.subject.MESH | Glucose | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Triglycerides | - |
dc.title | Incremental prognostic value of triglyceride glucose index additional to coronary artery calcium score in asymptomatic low-risk population | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Research Institute (부설연구소) | - |
dc.contributor.googleauthor | Shinjeong Song | - |
dc.contributor.googleauthor | Su-Yeon Choi | - |
dc.contributor.googleauthor | Hyo Eun Park | - |
dc.contributor.googleauthor | Hae-Won Han | - |
dc.contributor.googleauthor | Sung Hak Park | - |
dc.contributor.googleauthor | Jidong Sung | - |
dc.contributor.googleauthor | Hae Ok Jung | - |
dc.contributor.googleauthor | Ji Min Sung | - |
dc.contributor.googleauthor | Hyuk-Jae Chang | - |
dc.identifier.doi | 10.1186/s12933-022-01620-7 | - |
dc.contributor.localId | A01955 | - |
dc.contributor.localId | A04964 | - |
dc.contributor.localId | A03490 | - |
dc.relation.journalcode | J00460 | - |
dc.identifier.eissn | 1475-2840 | - |
dc.identifier.pmid | 36151571 | - |
dc.subject.keyword | Atherosclerotic cardiovascular disease | - |
dc.subject.keyword | Coronary artery calcification | - |
dc.subject.keyword | Triglyceride glucose index | - |
dc.contributor.alternativeName | Sung, Ji Min | - |
dc.contributor.affiliatedAuthor | 성지민 | - |
dc.contributor.affiliatedAuthor | 송신정 | - |
dc.contributor.affiliatedAuthor | 장혁재 | - |
dc.citation.volume | 21 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 193 | - |
dc.identifier.bibliographicCitation | CARDIOVASCULAR DIABETOLOGY, Vol.21(1) : 193, 2022-09 | - |
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