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Treatment of eating disorders: A systematic meta-review of meta-analyses and network meta-analyses

Authors
 Alessio Maria Monteleone  ;  Francesca Pellegrino  ;  Giovanni Croatto  ;  Marco Carfagno  ;  Anja Hilbert  ;  Janet Treasure  ;  Tracey Wade  ;  Cynthia M Bulik  ;  Stephan Zipfel  ;  Phillipa Hay  ;  Ulrike Schmidt  ;  Giovanni Castellini  ;  Angela Favaro  ;  Fernando Fernandez-Aranda  ;  Jae Il Shin  ;  Ulrich Voderholzer  ;  Valdo Ricca  ;  Davide Moretti  ;  Daniele Busatta  ;  Giovanni Abbate-Daga  ;  Filippo Ciullini  ;  Giammarco Cascino  ;  Francesco Monaco  ;  Christoph U Correll  ;  Marco Solmi 
Citation
 NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, Vol.142 : 104857, 2022-11 
Journal Title
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
ISSN
 0149-7634 
Issue Date
2022-11
MeSH
Adolescent ; Adult ; Antidepressive Agents / therapeutic use ; Binge-Eating Disorder* / drug therapy ; Binge-Eating Disorder* / psychology ; Bulimia Nervosa* ; Bulimia* / drug therapy ; Feeding and Eating Disorders* / drug therapy ; Humans ; Meta-Analysis as Topic ; Network Meta-Analysis
Keywords
Eating disorders ; Psychopharmacology ; Psychotherapy ; Randomized controlled trials ; Treatment ; Umbrella review
Abstract
MONTELEONE, A.M., F. Pellegrino, G. Croatto, M. Carfagno, A. Hilbert, J. Treasure, T. Wade, C. Bulik, S. Zipfel, P. Hay, U. Schmidt, G. Castellini, A. Favaro, F. Fernandez-Aranda, J. Il Shin, U. Voderholzer, V. Ricca, D. Moretti, D. Busatta, G. Abbate-Daga, F. Ciullini, G. Cascino, F. Monaco, C.U. Correll and M. Solmi. Treatment of Eating Disorders: a systematic meta-review of meta-analyses and network meta-analyses. NEUROSCI BIOBEHAV REV 21(1) XXX-XXX, 2022.- Treatment efficacy for eating disorders (EDs) is modest and guidelines differ. We summarized findings/quality of (network) meta-analyses (N)MA of randomized controlled trials (RCTs) in EDs. Systematic meta-review ((N)MA of RCTs, ED, active/inactive control), using (anorexia or bulimia or eating disorder) AND (meta-analy*) in PubMed/PsycINFO/Cochrane database up to December 15th, 2020. Standardized mean difference, odds/risk ratio vs control were summarized at end of treatment and follow-up. Interventions involving family (family-based therapy, FBT) outperformed active control in adults/adolescents with anorexia nervosa (AN), and in adolescents with bulimia nervosa (BN). In adults with BN, individual cognitive behavioural therapy (CBT)-ED had the broadest efficacy versus active control; also, antidepressants outperformed active. In mixed age groups with binge-eating disorder (BED), psychotherapy, and lisdexamfetamine outperformed active control. Antidepressants, stimulants outperformed placebo, despite lower acceptability, as did CBT-ED versus waitlist/no treatment. Family-based therapy is effective in AN and BN (adolescents). CBT-ED has the largest efficacy in BN (adults), followed by antidepressants, as well as psychotherapy in BED (mixed). Medications have short-term efficacy in BED (adults).
Full Text
https://www.sciencedirect.com/science/article/pii/S0149763422003463
DOI
10.1016/j.neubiorev.2022.104857
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/193341
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