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Mesonephric-like Carcinosarcoma of the Uterine Corpus: Clinicopathological, Molecular and Prognostic Characteristics in Comparison With Uterine Mesonephric-like Adenocarcinoma and Conventional Endometrial Carcinosarcoma

Authors
 Sujin Park  ;  Eunhyang Park  ;  Hyun-Soo Kim 
Citation
 CANCER GENOMICS & PROTEOMICS, Vol.19(6) : 747-760, 2022-11 
Journal Title
CANCER GENOMICS & PROTEOMICS
ISSN
 1109-6535 
Issue Date
2022-11
MeSH
Adenocarcinoma* / pathology ; Carcinosarcoma* / genetics ; Carcinosarcoma* / pathology ; Endometrial Neoplasms* / genetics ; Endometrial Neoplasms* / pathology ; Female ; Humans ; Prognosis
Keywords
TP53 ; Uterus ; carcinosarcoma ; mesonephric-like adenocarcinoma ; mesonephric-like carcinosarcoma ; tumor protein 53
Abstract
Background/aim: This study aimed to investigate the clinicopathological, prognostic and molecular characteristics of uterine mesonephric-like carcinosarcoma (MLCS).

Patients and methods: We collected clinical, pathological, and genetic information from 12 MLCS patients, and analyzed their differences from mesonephric-like adenocarcinoma (MLA) and conventional endometrial carcinosarcoma (CECS).

Results: The epithelial component was exclusively MLA in all MLCS cases. Metastatic and recurrent tumors consisted predominantly or exclusively of MLA in the majority of MLCS cases. Patients with MLCS and MLA presented with more advanced-stage disease than those with CECS. They also exhibited post-treatment recurrence and lung metastases more frequently than CECS. Disease-free survival rates of MLCS and MLA were shorter than those of CECS. Tumor protein 53 gene mutations were detected in four MLCS cases.

Conclusion: The predominance or exclusive presence of MLA in metastatic and recurrent tumors highlights the possibility that MLA may determine the clinical outcomes of patients with MLCS. Further studies are required to provide direct molecular evidence of the monoclonal origin of uterine MLCS.
Files in This Item:
T202300633.pdf Download
DOI
10.21873/cgp.20357
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Park, Eunhyang(박은향) ORCID logo https://orcid.org/0000-0003-2658-5054
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/193122
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