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Regulatory mechanisms of the store-operated Ca2+ entry through Orai1 and STIM1 by an adaptor protein in non-excitable cells
DC Field | Value | Language |
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dc.contributor.author | 양유미 | - |
dc.date.accessioned | 2023-03-10T01:14:04Z | - |
dc.date.available | 2023-03-10T01:14:04Z | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 1226-7155 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193076 | - |
dc.description.abstract | Store-operated Ca2+ entry (SOCE) represents one of the major Ca2+ entry routes in non-excitable cells. It is involved in a variety of fundamental biological processes and the maintenance of Ca2+ homeostasis. The Ca2+ releaseactivated Ca2+ (CRAC) channel consists of stromal interaction molecule and Orai; however, the role and action of Homer proteins as an adaptor protein to SOCE-mediated Ca2+ signaling through the activation of CRAC channels in non-excitable cells still remain unknown. In the present study, we investigated the role of Homer2 in the process of Ca2+ signaling induced by the interaction between CRACs and Homer2 proteins in non-excitable cells. The response to Ca2+ entry by thapsigargin-mediated Ca2+ store depletion remarkably decreased in pancreatic acinar cells of Homer2–/– mice, as compared to wild-type cells. It also showed critical differences in regulated patterns by the specific blockers of SOCE in pancreatic acinar cells of Homer2–/– mice. The response to Ca2+ entry by the depletion in Ca2+ store markedly increased in the cellular overexpression of Orai1 and STIM1 as compared to the overexpression of Homer2 in cells; however, this response was remarkably inhibited by the overexpression of Orai1, STIM1, and Homer2. These results suggest that Homer2 has a critical role in the regulatory action of SOCE activity and the interactions between CRAC channels. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Harn Rim Won Printing Co. | - |
dc.relation.isPartOf | International Journal of Oral Biology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Regulatory mechanisms of the store-operated Ca2+ entry through Orai1 and STIM1 by an adaptor protein in non-excitable cells | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학교실) | - |
dc.contributor.googleauthor | Jung Yun Kang | - |
dc.contributor.googleauthor | Yu-Mi Yang | - |
dc.identifier.doi | 10.11620/IJOB.2022.47.3.33 | - |
dc.contributor.localId | A05148 | - |
dc.relation.journalcode | J01144 | - |
dc.subject.keyword | Calcium signaling | - |
dc.subject.keyword | Ion channel gating | - |
dc.subject.keyword | Orai1 protein | - |
dc.subject.keyword | Stromal interaction molecule 1 | - |
dc.contributor.alternativeName | Yang, Yu Mi | - |
dc.contributor.affiliatedAuthor | 양유미 | - |
dc.citation.volume | 47 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 33 | - |
dc.citation.endPage | 40 | - |
dc.identifier.bibliographicCitation | International Journal of Oral Biology, Vol.47(3) : 33-40, 2022-09 | - |
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