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Prognosis of Anaplastic Thyroid Cancer with Distant Metastasis

Authors
 Jin-Seok Lee  ;  Jun Sung Lee  ;  Hyeok Jun Yun  ;  Hojin Chang  ;  Seok Mo Kim  ;  Yong Sang Lee  ;  Hang-Seok Chang  ;  Cheong Soo Park 
Citation
 CANCERS, Vol.14(23) : 5784, 2022-11 
Journal Title
CANCERS
Issue Date
2022-11
Keywords
anaplastic thyroid cancer ; brain metastasis ; distant metastasis ; prognosis of anaplastic cancer
Abstract
Anaplastic thyroid cancer (ATC) is derived from follicular thyroid cells and is associated with high mortality risk. Obtaining information to characterize ATC is difficult because ATC with distant metastasis is extremely rare. This study determined the clinical characteristics of ATC with distant metastasis. The medical records of 152 patients with ATC at Gangnam Severance Hospital were reviewed between January 2004 and March 2022. The primary endpoint was the overall survival of the total patient sample, patients with ATC and distant metastasis, and those with ATC and brain metastasis. Of the 152 patients with ATC, 88 had distant metastasis at diagnosis. The 5-year disease-specific survival was 24% for total ATC and 10% for ATC with distant metastasis. Survival for >1 year was 32% for total ATC and 15% for ATC with distant metastasis. The median survival rate differed significantly between the total ATC and ATC with distant metastasis groups (228.5 vs. 171 days). Among the ATC cases, 11% had brain metastasis; thus, brain MRI or CT is worth considering at diagnosis and follow-up, even if there were no statistical difference in overall survival between patients with ATC with and without brain metastasis.
Files in This Item:
T202300122.pdf Download
DOI
10.3390/cancers14235784
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seok Mo(김석모) ORCID logo https://orcid.org/0000-0001-8070-0573
Park, Cheong Soo(박정수)
Yun, Hyeok Jun(윤혁준) ORCID logo https://orcid.org/0000-0001-6004-0782
Lee, Yong Sang(이용상) ORCID logo https://orcid.org/0000-0002-8234-8718
Lee, Jun Sang(이준상) ORCID logo https://orcid.org/0000-0002-4054-6900
Lee, Jin-Seok(이진석)
Chang, Hang Seok(장항석) ORCID logo https://orcid.org/0000-0002-5162-103X
Chang, Ho Jin(장호진) ORCID logo https://orcid.org/0000-0002-8940-3484
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/193056
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