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Allogeneic Demineralized Dentin Matrix as rhBMP-2 Carrier: A Retrospective Clinical Study

Authors
 Jeong-Kui Ku  ;  Young-Kyun Kim  ;  Jong-Ki Huh  ;  In-Woong Um  ;  Eui Seok Lee  ;  Chungyeul Kim 
Citation
 INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS, Vol.37(6) : 1138-1144, 2022-11 
Journal Title
INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS
ISSN
 0882-2786 
Issue Date
2022-11
MeSH
Bone Resorption* ; Hematopoietic Stem Cell Transplantation* ; Humans ; Retrospective Studies
Abstract
Purpose: To compare the clinical outcomes of autogenous and allogeneic demineralized dentin matrices loaded with recombinant human bone morphogenetic protein-2 (rhBMP-2; auto- and allo-DDM/rhBMP-2) by measuring the buccal marginal bone resorption around dental implants.

Materials and methods: This retrospective study included patients who underwent dental implant placement with auto-DDM/rhBMP-2 as the control group and allo-DDM/rhBMP-2 as the experimental group. The primary outcome was buccal marginal bone resorption on CBCT. The resorption was calculated during T0 (from surgery to prosthetic loading), T1 (during the first year after loading), and T2 (during the second year after loading). The secondary outcome was the histologic analysis of five specimens of each group, obtained during the prosthetic procedure.

Results: Among the 103 implants, 61 and 42 implants were placed with auto- and allo-DDM/rhBMP-2 matrices, respectively. The resorptions of all periods were similar between the groups (T0: 0.65 ± 0.71 and 0.67 ± 0.81 mm, T1: 0.55 ± 0.60 and 0.59 ± 0.81 mm, and T2: 0.29 ± 0.45 and 0.20 ± 0.30 mm with auto- and allo-DDM/rhBMP-2, respectively). The histologic and histomorphometric analysis revealed similar osteoinductive aspects and proportions of new bone between the groups.

Conclusion: Allo-DDM/rhBMP-2 showed comparable outcomes in terms of buccal marginal bone resorption to auto-DDM/rhBMP-2 during the second year after loading.
Full Text
http://quintpub.com/journals/omi/abstract.php?iss2_id=1839&article_id=22768
DOI
10.11607/jomi.9692
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Huh, Jong Ki(허종기) ORCID logo https://orcid.org/0000-0002-7381-3972
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/192968
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