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High serum levels of L-carnitine and citric acid negatively correlated with alkaline phosphatase are detectable in Koreans before gastric cancer onset

 Youngmin Han  ;  Hye Jin Yoo  ;  Sun Ha Jee  ;  Jong Ho Lee 
 METABOLOMICS, Vol.18(8) : 62, 2022-07 
Journal Title
Issue Date
Alkaline Phosphatase ; Biomarkers ; Carnitine ; Citric Acid ; Humans ; Metabolomics ; Republic of Korea ; Stomach Neoplasms* / diagnosis ; Stomach Neoplasms* / metabolism
Acyl-carnitine ; Alkaline phosphatase ; Carnitine ; Disease prediction ; Gastric cancer ; Metabolomics
Introduction: Monitoring metabolic biomarkers could be utilized as an effective tool for the early detection of gastric cancer (GC) risk.

Objective: We aimed to discover predictive serum biomarkers for GC and investigate biomarker-related metabolism.

Methods: Subjects were randomly selected from the Korean Cancer Prevention Study-II cohort and matched by age and sex. We analyzed baseline serum samples of 160 subjects (discovery set; control and GC occurrence group, 80 each) via nontargeted screening. Identified putative biomarkers were validated in baseline serum samples of 140 subjects (validation set; control and GC occurrence group, 70 each) using targeted metabolites analysis.

Results: The final analysis was conducted on the discovery set (control, n = 52 vs. GC occurrence, n = 50) and the validation set (control, n = 43 vs. GC occurrence, n = 44) applying exclusion conditions. Eighteen putative metabolite sets differed between two groups found on nontargeted metabolic screening. We focused on fatty acid-related energy metabolism. In targeted analysis, levels of decanoyl-L-carnitine (p = 0.019), L-carnitine (p = 0.033), and citric acid (p = 0.025) were significantly lower in the GC occurrence group, even after adjusting for age, sex, and smoking status. Additionally, L-carnitine and citric acid were confirmed to have an independently significant relationship to GC development. Notably, alkaline phosphatase showed a significant correlation with these two biomarkers.

Conclusion: Changes in serum L-carnitine and citric acid levels that may result from alterations of fatty-acid-related energy metabolism are expected to be valuable biomarkers for the early diagnosis of GC risk.
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4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
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