Cited 3 times in
Lipid Accumulation Product Index Predicts New-Onset Type 2 Diabetes Among Non-Obese Koreans: A 12-Year Longitudinal Study
DC Field | Value | Language |
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dc.contributor.author | 박병진 | - |
dc.contributor.author | 윤지현 | - |
dc.contributor.author | 이용제 | - |
dc.contributor.author | 정동혁 | - |
dc.date.accessioned | 2023-03-03T02:22:50Z | - |
dc.date.available | 2023-03-03T02:22:50Z | - |
dc.date.issued | 2022-12 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/192813 | - |
dc.description.abstract | Purpose: The lipid accumulation product (LAP) has been a potential indicator of central lipid accumulation status. This study aimed to assess the longitudinal association between LAP index and incident type 2 diabetes among non-obese Korean adults using a large, community-based Korean cohort observed over 12 years. Patients and methods: This study included 4281 non-diabetic adults without generalized obesity and abdominal obesity and aged 40-69 years from the Korean Genome and Epidemiology Study. The participants were divided into four groups according to LAP index quartiles, calculated as (waist circumference [cm] - 65) x (triglycerides [mmol/L]) in men and (waist circumference [cm] - 58) x (triglycerides [mmol/L]) in women. We prospectively assessed hazard ratios (HRs) with 95% confidential intervals (CIs) for incident type 2 diabetes using multivariate Cox proportional hazard regression models. Results: Overall, 608 (14.2%) participants developed type 2 diabetes during the follow-up period. HRs for incident type 2 diabetes in the second, third, and fourth LAP quartile were 1.32 (95% CI: 0.97-1.79), 1.51 (95% CI: 1.11-2.06), and 2.14 (95% CI: 1.56-2.94), respectively, after adjusting for age, sex, body mass index, smoking status, alcohol intake, physical activity, mean arterial blood pressure, family history of diabetes, and impaired glucose tolerance. Conclusion: A high LAP index can be an additional indicator for new-onset T2DM among middle-aged and elderly non-obese Koreans. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Dove Medical Press | - |
dc.relation.isPartOf | DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Lipid Accumulation Product Index Predicts New-Onset Type 2 Diabetes Among Non-Obese Koreans: A 12-Year Longitudinal Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학교실) | - |
dc.contributor.googleauthor | Seung Ho Yang | - |
dc.contributor.googleauthor | Jihyun Yoon | - |
dc.contributor.googleauthor | Yong-Jae Lee | - |
dc.contributor.googleauthor | Byoungjin Park | - |
dc.contributor.googleauthor | Dong-Hyuk Jung | - |
dc.identifier.doi | 10.2147/DMSO.S389889 | - |
dc.contributor.localId | A01477 | - |
dc.contributor.localId | A06126 | - |
dc.contributor.localId | A02982 | - |
dc.contributor.localId | A03595 | - |
dc.relation.journalcode | J03921 | - |
dc.identifier.eissn | 1178-7007 | - |
dc.identifier.pmid | 36474727 | - |
dc.subject.keyword | Koreans | - |
dc.subject.keyword | incident type 2 diabetes | - |
dc.subject.keyword | lipid accumulation product index | - |
dc.subject.keyword | prospective cohort study | - |
dc.contributor.alternativeName | Park, Byoung Jin | - |
dc.contributor.affiliatedAuthor | 박병진 | - |
dc.contributor.affiliatedAuthor | 윤지현 | - |
dc.contributor.affiliatedAuthor | 이용제 | - |
dc.contributor.affiliatedAuthor | 정동혁 | - |
dc.citation.volume | 15 | - |
dc.citation.startPage | 3729 | - |
dc.citation.endPage | 3737 | - |
dc.identifier.bibliographicCitation | DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY, Vol.15 : 3729-3737, 2022-12 | - |
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