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Investigation of gene-environment interactions in relation to tic severity

Authors
 Mohamed Abdulkadir  ;  Dongmei Yu  ;  Lisa Osiecki  ;  Robert A King  ;  Thomas V Fernandez  ;  Lawrence W Brown  ;  Keun-Ah Cheon  ;  Barbara J Coffey  ;  Blanca Garcia-Delgar  ;  Donald L Gilbert  ;  Dorothy E Grice  ;  Julie Hagstrøm  ;  Tammy Hedderly  ;  Isobel Heyman  ;  Hyun Ju Hong  ;  Chaim Huyser  ;  Laura Ibanez-Gomez  ;  Young Key Kim  ;  Young-Shin Kim  ;  Yun-Joo Koh  ;  Sodahm Kook  ;  Samuel Kuperman  ;  Bennett Leventhal  ;  Marcos Madruga-Garrido  ;  Athanasios Maras  ;  Pablo Mir  ;  Astrid Morer  ;  Alexander Münchau  ;  Kerstin J Plessen  ;  Veit Roessner  ;  Eun-Young Shin  ;  Dong-Ho Song  ;  Jungeun Song  ;  Frank Visscher  ;  Samuel H Zinner  ;  Carol A Mathews  ;  Jeremiah M Scharf  ;  Jay A Tischfield  ;  Gary A Heiman  ;  Andrea Dietrich  ;  Pieter J Hoekstra 
Citation
 JOURNAL OF NEURAL TRANSMISSION, Vol.128(11) : 1757-1765, 2021-11 
Journal Title
JOURNAL OF NEURAL TRANSMISSION
ISSN
 0300-9564 
Issue Date
2021-11
MeSH
Attention Deficit Disorder with Hyperactivity* / genetics ; Autism Spectrum Disorder* / genetics ; Female ; Gene-Environment Interaction ; Genome-Wide Association Study ; Humans ; Pregnancy ; Severity of Illness Index ; Tics* ; Tourette Syndrome*
Keywords
Gene–environment interaction ; Pre- and perinatal complications ; Tic severity ; Tourette syndrome
Abstract
Tourette syndrome (TS) is a neuropsychiatric disorder with involvement of genetic and environmental factors. We investigated genetic loci previously implicated in Tourette syndrome and associated disorders in interaction with pre- and perinatal adversity in relation to tic severity using a case-only (N = 518) design. We assessed 98 single-nucleotide polymorphisms (SNPs) selected from (I) top SNPs from genome-wide association studies (GWASs) of TS; (II) top SNPs from GWASs of obsessive-compulsive disorder (OCD), attention-deficit/hyperactivity disorder (ADHD), and autism spectrum disorder (ASD); (III) SNPs previously implicated in candidate-gene studies of TS; (IV) SNPs previously implicated in OCD or ASD; and (V) tagging SNPs in neurotransmitter-related candidate genes. Linear regression models were used to examine the main effects of the SNPs on tic severity, and the interaction effect of these SNPs with a cumulative pre- and perinatal adversity score. Replication was sought for SNPs that met the threshold of significance (after correcting for multiple testing) in a replication sample (N = 678). One SNP (rs7123010), previously implicated in a TS meta-analysis, was significantly related to higher tic severity. We found a gene-environment interaction for rs6539267, another top TS GWAS SNP. These findings were not independently replicated. Our study highlights the future potential of TS GWAS top hits in gene-environment studies.
Files in This Item:
T9992021125.pdf Download
DOI
10.1007/s00702-021-02396-y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Song, Dong Ho(송동호) ORCID logo https://orcid.org/0000-0002-9647-3130
Cheon, Keun Ah(천근아) ORCID logo https://orcid.org/0000-0001-7113-9286
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/192408
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