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Noma disease (cancrum oris, orofacial gangrene) in an acute myeloid leukemia patient: a case report

 Jiho Park  ;  Sanghun Kim  ;  Seung-Woo Shin  ;  Chuhl Joo Lyu  ;  Dongwook Kim 
 Journal of Medical Case Reports, Vol.16(1) : 97, 2022-12 
Journal Title
Journal of Medical Case Reports
Issue Date
Child ; Face ; Female ; Gangrene / complications ; Humans ; Leukemia, Myeloid, Acute* / complications ; Leukemia, Myeloid, Acute* / diagnosis ; Malnutrition* / complications ; Noma* / complications ; Noma* / diagnosis
Acute myeloid leukemia ; Cancrum oris ; Facial disfigurement ; Noma ; Orofacial gangrene
Background: Noma is a rare disease that occurs mainly in malnourished patients in developing countries. Noma starts as facial swelling and gingival necrosis that eventually necrotizes underlying tissues including the jaw bone, leaving severe disfigurement. It is reported extremely rarely in patients with severe immunosuppression or blood dyscrasia.

Case presentation: The gingivitis that occurred in a 12-year-old Asian female patient with acute myeloid leukemia was getting increasingly worse. Although the proper treatment was done, the patient's condition did not improve, and eventually, a large full-thickness defect was left in the maxillofacial part.

Conclusions: Early diagnosis and management is the only way to prevent the progression, which leads to facial disfigurement. We present a case of noma in a pediatric acute myeloid leukemia patient, in which oral function was restored through surgical intervention.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Wook(김동욱) ORCID logo https://orcid.org/0000-0001-6167-6475
Lyu, Chuhl Joo(유철주) ORCID logo https://orcid.org/0000-0001-7124-7818
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