Cited 4 times in
Suppressed prefrontal neuronal firing variability and impaired social representation in IRSp53-mutant mice
DC Field | Value | Language |
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dc.contributor.author | 이은이 | - |
dc.date.accessioned | 2022-12-22T05:05:52Z | - |
dc.date.available | 2022-12-22T05:05:52Z | - |
dc.date.issued | 2022-11 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/192304 | - |
dc.description.abstract | Social deficit is a major feature of neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, and attention-deficit/hyperactivity disorder, but its neural mechanisms remain unclear. Here, we examined neuronal discharge characteristics in the medial prefrontal cortex (mPFC) of IRSp53/Baiap2-mutant mice, which show social deficits, during social approach. We found a decrease in the proportion of IRSp53-mutant excitatory mPFC neurons encoding social information, but not that encoding non-social information. In addition, the firing activity of IRSp53-mutant neurons was less differential between social and non-social targets. IRSp53-mutant excitatory mPFC neurons displayed an increase in baseline neuronal firing, but decreases in the variability and dynamic range of firing as well as burst firing during social and non-social target approaches compared to wild-type controls. Treatment of memantine, an NMDA receptor antagonist that rescues social deficit in IRSp53-mutant mice, alleviates the reduced burst firing of IRSp53-mutant pyramidal mPFC neurons. These results suggest that suppressed neuronal activity dynamics and burst firing may underlie impaired cortical encoding of social information and social behaviors in IRSp53-mutant mice. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Sciences Publications | - |
dc.relation.isPartOf | ELIFE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Neurons* / physiology | - |
dc.subject.MESH | Prefrontal Cortex / physiology | - |
dc.subject.MESH | Pyramidal Cells / metabolism | - |
dc.subject.MESH | Receptors, N-Methyl-D-Aspartate / genetics | - |
dc.subject.MESH | Receptors, N-Methyl-D-Aspartate / metabolism | - |
dc.subject.MESH | Schizophrenia* | - |
dc.title | Suppressed prefrontal neuronal firing variability and impaired social representation in IRSp53-mutant mice | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anatomy (해부학교실) | - |
dc.contributor.googleauthor | Woohyun Kim | - |
dc.contributor.googleauthor | Jae Jin Shin | - |
dc.contributor.googleauthor | Yu Jin Jeong | - |
dc.contributor.googleauthor | Kyungdeok Kim | - |
dc.contributor.googleauthor | Jung Won Bae | - |
dc.contributor.googleauthor | Young Woo Noh | - |
dc.contributor.googleauthor | Seungjoon Lee | - |
dc.contributor.googleauthor | Woochul Choi | - |
dc.contributor.googleauthor | Se-Bum Paik | - |
dc.contributor.googleauthor | Min Whan Jung | - |
dc.contributor.googleauthor | Eunee Lee | - |
dc.contributor.googleauthor | Eunjoon Kim | - |
dc.identifier.doi | 10.7554/elife.74998 | - |
dc.contributor.localId | A06099 | - |
dc.relation.journalcode | J03902 | - |
dc.identifier.eissn | 2050-084X | - |
dc.identifier.pmid | 36317872 | - |
dc.subject.keyword | BAIAP2 | - |
dc.subject.keyword | IRSp53 | - |
dc.subject.keyword | firing variability | - |
dc.subject.keyword | medial prefrontal cortex | - |
dc.subject.keyword | mouse | - |
dc.subject.keyword | neuroscience | - |
dc.subject.keyword | social behavior | - |
dc.subject.keyword | social deficit | - |
dc.contributor.alternativeName | Lee, Eunee | - |
dc.contributor.affiliatedAuthor | 이은이 | - |
dc.citation.volume | 11 | - |
dc.citation.startPage | e74998 | - |
dc.identifier.bibliographicCitation | ELIFE, Vol.11 : e74998, 2022-11 | - |
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