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The Pattern of Care for Brain Metastasis from Breast Cancer over the Past 10 Years in Korea: A Multicenter Retrospective Study (KROG 16-12)

Authors
 Jae Sik Kim  ;  Kyubo Kim  ;  Wonguen Jung  ;  Kyung Hwan Shin  ;  Seock-Ah Im  ;  Hee-Jun Kim  ;  Yong Bae Kim  ;  Jee Suk Chang  ;  Jee Hyun Kim  ;  Doo Ho Choi  ;  Yeon Hee Park  ;  Dae Yong Kim  ;  Tae Hyun Kim  ;  Byung Ock Choi  ;  Sea-Won Lee  ;  Suzy Kim  ;  Jeanny Kwon  ;  Ki Mun Kang  ;  Woong-Ki Chung  ;  Kyung Su Kim  ;  Ji Ho Nam  ;  Won Sup Yoon  ;  Jin Hee Kim  ;  Jihye Cha  ;  Yoon Kyeong Oh  ;  In Ah Kim 
Citation
 CANCER RESEARCH AND TREATMENT, Vol.54(4) : 1121-1129, 2022-10 
Journal Title
CANCER RESEARCH AND TREATMENT
ISSN
 1598-2998 
Issue Date
2022-10
MeSH
Brain Neoplasms* / epidemiology ; Brain Neoplasms* / secondary ; Brain Neoplasms* / therapy ; Breast Neoplasms* / pathology ; Child, Preschool ; Female ; Humans ; Prognosis ; Radiosurgery* ; Republic of Korea / epidemiology ; Retrospective Studies
Keywords
Brain metastasis ; Breast neoplasms ; Overall survival ; Pattern of care study
Abstract
Purpose: We aimed to investigate manifestations and patterns of care for patients with brain metastasis (BM) from breast cancer (BC) and compared their overall survival (OS) from 2005 through 2014 in Korea.

Materials and methods: We retrospectively reviewed 600 BC patients with BM diagnosed between 2005 and 2014. The median follow-up duration was 12.5 months. We categorized the patients into three groups according to the year when BM was initially diagnosed (group I [2005-2008], 98 patients; group II [2009-2011], 200 patients; and group III [2012-2014], 302 patients).

Results: Over time, the median age at BM diagnosis increased by 2.2 years (group I, 49.0 years; group II, 48.3 years; and group III, 51.2 years; p=0.008). The percentage of patients with extracranial metastasis was 73.5%, 83.5%, and 86.4% for group I, II, and III, respectively (p=0.011). The time interval between BC and BM was prolonged in patients with stage III primary BC (median, 2.4 to 3 years; p=0.029). As an initial brain-directed treatment, whole-brain radiotherapy alone decreased from 80.0% in 2005 to 41.1% in 2014. Meanwhile, stereotactic radiosurgery or fractionated stereotactic radiotherapy alone increased from 13.3% to 34.7% during the same period (p=0.005). The median OS for group I, II, and III was 15.6, 17.9, and 15.0 months, respectively, with no statistical significance.

Conclusion: The manifestations of BM from BC and the pattern of care have changed from 2005 to 2014 in Korea. However, the OS has remained relatively unchanged over the 10 years.
Files in This Item:
T202204783.pdf Download
DOI
10.4143/crt.2021.1083
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yong Bae(김용배) ORCID logo https://orcid.org/0000-0001-7573-6862
Chang, Jee Suk(장지석) ORCID logo https://orcid.org/0000-0001-7685-3382
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/192171
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