0 291

Cited 1 times in

Regulation of the Inevitable Water-Responsivity of Silk Fibroin Biopolymer by Polar Amino Acid Activation

DC Field Value Language
dc.contributor.author권재성-
dc.contributor.author차재국-
dc.date.accessioned2022-12-22T04:30:55Z-
dc.date.available2022-12-22T04:30:55Z-
dc.date.issued2022-10-
dc.identifier.issn1936-0851-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/192153-
dc.description.abstractIn nature, water is vital for maintaining homeostasis. Particularly, organisms (e.g., plant leaf, bird feather) exploit water fluidics for motions. Hydration-adaptive crystallization is the representative water-responsive actuation of biopolymers. This crystallization has inspired the development of intelligent human-robot interfaces. At the same time, it hinders the consistent adhesion of tissue adhesive. As hydration-adaptive crystallization is inevitable, the on-demand control of crystallization is desirable in the innovative biopolymeric biomedical systems. To this end, this study developed an amino acid-based technology to artificially up- or down-regulate the inevitable crystallization of silk fibroin. A case II diffusion model was constructed, and it revealed that the activity of polar amino acid is related to crystallization kinetics. Furthermore, the water dynamics study suggested that active amino acid stabilizes crystallization-triggering water molecules. As a proof-of-concept, we verified that a 30% increase in the activity of serine resulted in a 50% decrease in the crystallization rate. Furthermore, the active amino acid-based suppression of hydration-adaptive crystallization enabled the silk fibroin to keep its robust adhesion (approximately 160 kJ m-3) by reducing the water-induced loss of adhesive force. The proposed silk fibroin was demonstrated as a stable tissue adhesive applied on ex vivo porcine mandible tissue. This amino acid-based regulation of hydration-adaptive crystallization will pioneer next-generation biopolymer-based healthcare.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAmerican Chemical Society-
dc.relation.isPartOfACS NANO-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAmino Acids-
dc.subject.MESHAnimals-
dc.subject.MESHBombyx* / chemistry-
dc.subject.MESHFibroins* / chemistry-
dc.subject.MESHHumans-
dc.subject.MESHSerine-
dc.subject.MESHSilk / chemistry-
dc.subject.MESHSwine-
dc.subject.MESHTissue Adhesives*-
dc.subject.MESHWater / chemistry-
dc.titleRegulation of the Inevitable Water-Responsivity of Silk Fibroin Biopolymer by Polar Amino Acid Activation-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실)-
dc.contributor.googleauthorWoojin Choi-
dc.contributor.googleauthorTaesuk Jun-
dc.contributor.googleauthorMilae Lee-
dc.contributor.googleauthorKyungtae Park-
dc.contributor.googleauthorMoonhyun Choi-
dc.contributor.googleauthorSungwon Jung-
dc.contributor.googleauthorJae-Kook Cha-
dc.contributor.googleauthorJae-Sung Kwon-
dc.contributor.googleauthorYoungho Jin-
dc.contributor.googleauthorSangmin Lee-
dc.contributor.googleauthorDu Yeol Ryu-
dc.contributor.googleauthorJinkee Hong-
dc.identifier.doi10.1021/acsnano.2c07971-
dc.contributor.localIdA00247-
dc.contributor.localIdA04004-
dc.relation.journalcodeJ00005-
dc.identifier.eissn1936-086X-
dc.identifier.pmid36129365-
dc.identifier.urlhttps://pubs.acs.org/doi/10.1021/acsnano.2c07971-
dc.subject.keywordamino acid-
dc.subject.keywordhydration-adaptive crystallization-
dc.subject.keywordsilk fibroin-
dc.subject.keywordtissue adhesive-
dc.subject.keywordwater diffusion-
dc.contributor.alternativeNameKwon, Jae-Sung-
dc.contributor.affiliatedAuthor권재성-
dc.contributor.affiliatedAuthor차재국-
dc.citation.volume16-
dc.citation.number10-
dc.citation.startPage17274-
dc.citation.endPage17288-
dc.identifier.bibliographicCitationACS NANO, Vol.16(10) : 17274-17288, 2022-10-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.