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The effect of pharmacological treatment and lifestyle modification in patients with nonalcoholic fatty liver disease: An umbrella review of meta-analyses of randomized controlled trials

 Kyuyeon Cho  ;  Seoyeon Park  ;  Ai Koyanagi  ;  Louis Jacob  ;  Dong Keon Yon  ;  Seung Won Lee  ;  Min Seo Kim  ;  Seung Up Kim  ;  Beom Kyung Kim  ;  Jae Il Shin  ;  Lee Smith 
 OBESITY REVIEWS, Vol.23(9) : e13464, 2022-09 
Journal Title
Issue Date
Exercise ; Humans ; Life Style ; Non-alcoholic Fatty Liver Disease* / drug therapy ; Randomized Controlled Trials as Topic
meta-analysis ; nonalcoholic fatty liver disease ; nonalcoholic steatohepatitis ; randomized controlled study
Nonalcoholic fatty liver disease (NAFLD) is a liver disease that affects approximately 25% of the world's population, and various treatments have been applied for NAFLD patients. We compared the effectiveness of each intervention conducted to treat NAFLD by evaluating meta-analyses of pharmacological interventions and lifestyle modification including diet and exercise. We searched Pubmed/Medline, Embase, and Cochrane Library and included meta-analyses of randomized controlled trials investigating the effects of pharmacological intervention and lifestyle modification on NAFLD. The quality of included meta-analyses was evaluated by AMSTAR-2. If the effect size was expressed as mean difference, it was converted to standardized mean difference based on the random-effects model. A total of 1694 meta-analyses were identified, and 27 meta-analyses were eventually included in the review. Regarding pharmacological interventions, there was a high strength of evidence for the ALT reduction effect of silymarin on inactive controls (SMD = 0.88, p < 0.01, seven trials, 518 participants). Meanwhile, it was confirmed that appropriate diet and exercise were important in reducing liver fat (SMD = 1.51, p < 0.01, 12 trials, 765 participants). This umbrella review assessed the effects of pharmacological interventions and lifestyle modifications in the treatment of NAFLD. The results of this review can be utilized for clinical decisions when treating NAFLD patients.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Beom Kyung(김범경) ORCID logo https://orcid.org/0000-0002-5363-2496
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
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