Cited 3 times in
Clinical Usefulness of Virtual Ablation Guided Catheter Ablation of Atrial Fibrillation Targeting Restitution Parameter-Guided Catheter Ablation: CUVIA-REGAB Prospective Randomized Study
DC Field | Value | Language |
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dc.contributor.author | 김대훈 | - |
dc.contributor.author | 김태훈 | - |
dc.contributor.author | 엄재선 | - |
dc.contributor.author | 유희태 | - |
dc.contributor.author | 이문형 | - |
dc.contributor.author | 정보영 | - |
dc.contributor.author | 박제욱 | - |
dc.contributor.author | 박희남 | - |
dc.contributor.author | 임병현 | - |
dc.contributor.author | 권오석 | - |
dc.date.accessioned | 2022-12-22T04:13:19Z | - |
dc.date.available | 2022-12-22T04:13:19Z | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/192074 | - |
dc.description.abstract | Background and objectives: We investigated whether extra-pulmonary vein (PV) ablation targeting a high maximal slope of the action potential duration restitution curve (Smax) improves the rhythm outcome of persistent atrial fibrillation (PeAF) ablation. Methods: In this open-label, multi-center, randomized, and controlled trial, 178 PeAF patients were randomized with 1:1 ratio to computational modeling-guided virtual Smax ablation (V-Smax) or empirical ablation (E-ABL) groups. Smax maps were generated by computational modeling based on atrial substrate maps acquired during clinical procedures in sinus rhythm. Smax maps were generated during the clinical PV isolation (PVI). The V-Smax group underwent an additional extra-PV ablation after PVI targeting the virtual high Smax sites. Results: After a mean follow-up period of 12.3±5.2 months, the clinical recurrence rates (25.6% vs. 23.9% in the V-Smax and the E-ABL group, p=0.880) or recurrence appearing as atrial tachycardia (11.1% vs. 5.7%, p=0.169) did not differ between the 2 groups. The post-ablation cardioversion rate was higher in the V-Smax group than E-ABL group (14.4% vs. 5.7%, p=0.027). Among antiarrhythmic drug-free patients (n=129), the AF freedom rate was 78.7% in the V-Smax group and 80.9% in the E-ABL group (p=0.776). The total procedure time was longer in the V-Smax group (p=0.008), but no significant difference was found in the major complication rates (p=0.497) between the groups. Conclusions: Unlike a dominant frequency ablation, the computational modeling-guided V-Smax ablation did not improve the rhythm outcome of the PeAF ablation and had a longer procedure time. Trial registration: ClinicalTrials.gov Identifier: NCT02558699. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English, Korean | - |
dc.publisher | Korean Society of Circulation | - |
dc.relation.isPartOf | KOREAN CIRCULATION JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Clinical Usefulness of Virtual Ablation Guided Catheter Ablation of Atrial Fibrillation Targeting Restitution Parameter-Guided Catheter Ablation: CUVIA-REGAB Prospective Randomized Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | BioMedical Science Institute (의생명과학부) | - |
dc.contributor.googleauthor | Young Choi | - |
dc.contributor.googleauthor | Byounghyun Lim | - |
dc.contributor.googleauthor | Song-Yi Yang | - |
dc.contributor.googleauthor | So-Hyun Yang | - |
dc.contributor.googleauthor | Oh-Seok Kwon | - |
dc.contributor.googleauthor | Daehoon Kim | - |
dc.contributor.googleauthor | Yun Gi Kim | - |
dc.contributor.googleauthor | Je-Wook Park | - |
dc.contributor.googleauthor | Hee Tae Yu | - |
dc.contributor.googleauthor | Tae-Hoon Kim | - |
dc.contributor.googleauthor | Pil-Sung Yang | - |
dc.contributor.googleauthor | Jae-Sun Uhm | - |
dc.contributor.googleauthor | Jamin Shim | - |
dc.contributor.googleauthor | Sung Hwan Kim | - |
dc.contributor.googleauthor | Jung-Hoon Sung | - |
dc.contributor.googleauthor | Jong-Il Choi | - |
dc.contributor.googleauthor | Boyoung Joung | - |
dc.contributor.googleauthor | Moon-Hyoung Lee | - |
dc.contributor.googleauthor | Young-Hoon Kim | - |
dc.contributor.googleauthor | Yong-Seog Oh | - |
dc.contributor.googleauthor | Hui-Nam Pak | - |
dc.identifier.doi | 10.4070/kcj.2022.0113 | - |
dc.contributor.localId | A06119 | - |
dc.contributor.localId | A00373 | - |
dc.contributor.localId | A01085 | - |
dc.contributor.localId | A02337 | - |
dc.contributor.localId | A02535 | - |
dc.contributor.localId | A02766 | - |
dc.contributor.localId | A03609 | - |
dc.contributor.localId | A04574 | - |
dc.contributor.localId | A01776 | - |
dc.relation.journalcode | J01952 | - |
dc.identifier.eissn | 1738-5555 | - |
dc.identifier.pmid | 35927040 | - |
dc.subject.keyword | Action potential | - |
dc.subject.keyword | Atrial fibrillation | - |
dc.subject.keyword | Catheter ablation | - |
dc.subject.keyword | Computer simulation | - |
dc.subject.keyword | Electrophysiology | - |
dc.contributor.alternativeName | Kwon, Oh-Seok | - |
dc.contributor.affiliatedAuthor | 권오석 | - |
dc.contributor.affiliatedAuthor | 김대훈 | - |
dc.contributor.affiliatedAuthor | 김태훈 | - |
dc.contributor.affiliatedAuthor | 엄재선 | - |
dc.contributor.affiliatedAuthor | 유희태 | - |
dc.contributor.affiliatedAuthor | 이문형 | - |
dc.contributor.affiliatedAuthor | 정보영 | - |
dc.contributor.affiliatedAuthor | 박제욱 | - |
dc.contributor.affiliatedAuthor | 박희남 | - |
dc.citation.volume | 52 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 699 | - |
dc.citation.endPage | 711 | - |
dc.identifier.bibliographicCitation | KOREAN CIRCULATION JOURNAL, Vol.52(9) : 699-711, 2022-09 | - |
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