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Humoral Immunogenicity to SARS-CoV-2 Vaccination in Liver Transplant Recipients: A Systematic Review and Meta-Analysis

Authors
 Jeong-Ju Yoo  ;  Dong Keon Yon  ;  Seung Won Lee  ;  Jae Il Shin  ;  Beom Kyung Kim 
Citation
 INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, Vol.18(15) : 5849-5857, 2022-09 
Journal Title
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
Issue Date
2022-09
MeSH
COVID-19 Vaccines ; COVID-19* / prevention & control ; Humans ; Immunosuppressive Agents / therapeutic use ; Liver Transplantation* ; Male ; SARS-CoV-2 ; Vaccination
Keywords
Meta-analysis ; SARS-CoV-2 ; immunogenicity ; liver transplant ; vaccine
Abstract
Solid organ transplant recipients generally show reduced immunogenicity to various vaccines. We aimed to assess the immunogenicity of the immune response among orthotopic liver transplant (OLT) recipients after the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. A systematic search was performed to evaluate immunogenicity or adverse events reported after SARS-CoV-2 vaccination. The pooled analysis of 20 studies showed a humoral immune response rate of 0.70 (95% confidence interval [CI], 0.63-0.77) after SARS-CoV-2 vaccination among OLT recipients. The immunogenicity among OLT recipients was significantly lower compared to the overall population and healthy controls, with odds ratios (ORs) of 0.80 and 0.69. However, it was significantly higher than that of patients receiving other organ transplants, especially kidneys, with an OR of 1.50. Male sex, old age, chronic kidney disease, obesity, and multiple or high immunosuppressant doses significantly increased the risk of unresponsiveness in patients with OLT. The overall incidence of any adverse event after vaccination was 0.68 (95% CI, 0.55-0.81), similar to that of control. OLT recipients had an overall humoral immune response rate of 70% after SARS-CoV-2 vaccination, which is lower than that of healthy controls but favourable compared to those of other solid organ transplant recipients.
Files in This Item:
T202204000.pdf Download
DOI
10.7150/ijbs.77030
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Beom Kyung(김범경) ORCID logo https://orcid.org/0000-0002-5363-2496
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/192034
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