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Association of resting-state theta-gamma coupling with selective visual attention in children with tic disorders

Authors
 Ji Seon Ahn  ;  Kyungun Jhung  ;  Jooyoung Oh  ;  Jaeseok Heo  ;  Jae-Jin Kim  ;  Jin Young Park 
Citation
 FRONTIERS IN HUMAN NEUROSCIENCE, Vol.16 : 1017703, 2022-09 
Journal Title
FRONTIERS IN HUMAN NEUROSCIENCE
Issue Date
2022-09
Keywords
electroencephalography ; neuronal oscillations ; resting state ; selective attention ; theta-gamma coupling ; tic disorder (TD)
Abstract
A tic disorder (TD) is a neurodevelopmental disorder characterized by tics, which are repetitive movements and/or vocalizations that occur due to aberrant sensory gating. Its pathophysiology involves dysfunction in multiple parts of the cortico-striato-thalamo-cortical circuits. Spontaneous brain activity during the resting state can be used to evaluate the baseline brain state, and it is associated with various aspects of behavior and cognitive processes. Theta-gamma coupling (TGC) is an emerging technique for examining how neural networks process information through interactions. However, the resting-state TGC of patients with TD and its correlation with cognitive function have not yet been studied. We investigated the resting-state TGC of 13 patients with TD and compared it with that of 13 age-matched healthy children. The participants underwent resting-state electroencephalography with their eyes closed. At the global level, patients with TD showed a significantly lower resting-state TGC than healthy children. Resting-state TGC with the eyes closed was significantly negatively correlated with the attention quotient calculated for omission errors in a selective visual attention test. These findings indicate that the resting-state brain network, which is important for the attentional processing of visual information, is dysfunctional in patients with TD. Additionally, these findings support the view that TGC reflects information processing and signal interactions at the global level. Patients with TD may have difficulty gating irrelevant sensory information in the resting state while their eyes are closed.
Files in This Item:
T202204921.pdf Download
DOI
10.3389/fnhum.2022.1017703
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Park, Jin Young(박진영) ORCID logo https://orcid.org/0000-0002-5351-9549
Oh, Jooyoung(오주영) ORCID logo https://orcid.org/0000-0001-6721-399X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/192010
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