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Cited 3 times in

Potential Link Between Cognition and Motor Reserve in Patients With Parkinson's Disease

DC Field Value Language
dc.contributor.author김윤중-
dc.contributor.author손영호-
dc.contributor.author이혜선-
dc.contributor.author정석종-
dc.contributor.author이필휴-
dc.contributor.author윤미진-
dc.date.accessioned2022-12-22T03:40:54Z-
dc.date.available2022-12-22T03:40:54Z-
dc.date.issued2022-09-
dc.identifier.issn2093-4939-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/191944-
dc.description.abstractObjective: To investigate whether there is a link between cognitive function and motor reserve (i.e., individual capacity to cope with nigrostriatal dopamine depletion) in patients with newly diagnosed Parkinson's disease (PD). Methods: A total of 163 patients with drug-naïve PD who underwent 18F-FP-CIT PET, brain MRI, and a detailed neuropsychological test were enrolled. We estimated individual motor reserve based on initial motor deficits and striatal dopamine depletion using a residual model. We performed correlation analyses between motor reserve estimates and cognitive composite scores. Diffusion connectometry analysis was performed to map the white matter fiber tracts, of which fractional anisotropy (FA) values were well correlated with motor reserve estimates. Additionally, Cox regression analysis was used to assess the effect of initial motor reserve on the risk of dementia conversion. Results: The motor reserve estimate was positively correlated with the composite score of the verbal memory function domain (γ = 0.246) and with the years of education (γ = 0.251). Connectometry analysis showed that FA values in the left fornix were positively correlated with the motor reserve estimate, while no fiber tracts were negatively correlated with the motor reserve estimate. Cox regression analysis demonstrated that higher motor reserve estimates tended to be associated with a lower risk of dementia conversion (hazard ratio, 0.781; 95% confidence interval, 0.576-1.058). Conclusion: The present study demonstrated that the motor reserve estimate was well correlated with verbal memory function and with white matter integrity in the left fornix, suggesting a possible link between cognition and motor reserve in patients with PD.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Movement Disorders Society-
dc.relation.isPartOfJOURNAL OF MOVEMENT DISORDERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePotential Link Between Cognition and Motor Reserve in Patients With Parkinson's Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorSeok Jong Chung-
dc.contributor.googleauthorYae Ji Kim-
dc.contributor.googleauthorYun Joong Kim-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorMijin Yun-
dc.contributor.googleauthorPhil Hyu Lee-
dc.contributor.googleauthorYong Jeong-
dc.contributor.googleauthorYoung H Sohn-
dc.identifier.doi10.14802/jmd.22063-
dc.contributor.localIdA00796-
dc.contributor.localIdA01982-
dc.contributor.localIdA03312-
dc.contributor.localIdA04666-
dc.contributor.localIdA03270-
dc.contributor.localIdA02550-
dc.relation.journalcodeJ01610-
dc.identifier.eissn2005-940X-
dc.identifier.pmid36065615-
dc.subject.keywordCognition-
dc.subject.keywordFornix-
dc.subject.keywordMemory-
dc.subject.keywordMotor reserve-
dc.subject.keywordParkinson’s disease-
dc.contributor.alternativeNameKim, Yun Joong-
dc.contributor.affiliatedAuthor김윤중-
dc.contributor.affiliatedAuthor손영호-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor정석종-
dc.contributor.affiliatedAuthor이필휴-
dc.contributor.affiliatedAuthor윤미진-
dc.citation.volume15-
dc.citation.number3-
dc.citation.startPage249-
dc.citation.endPage257-
dc.identifier.bibliographicCitationJOURNAL OF MOVEMENT DISORDERS, Vol.15(3) : 249-257, 2022-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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