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Effects of sarcopenia and sarcopenic obesity on joint pain and degenerative osteoarthritis in postmenopausal women

Authors
 Hye In Kim  ;  So Hyun Ahn  ;  Yup Kim  ;  Ji Eun Lee  ;  Euna Choi  ;  Seok Kyo Seo 
Citation
 SCIENTIFIC REPORTS, Vol.12(1) : 13,543, 2022-08 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2022-08
MeSH
Arthralgia / epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Obesity / complications ; Obesity / epidemiology ; Osteoarthritis, Knee* / complications ; Osteoarthritis, Knee* / diagnostic imaging ; Osteoarthritis, Knee* / epidemiology ; Postmenopause ; Sarcopenia* / complications ; Sarcopenia* / epidemiology
Abstract
This study aimed to identify the prevalence of sarcopenia, obesity, and sarcopenic obesity and examine their association with radiographic knee osteoarthritis (OA) and knee pain in Korean postmenopausal women. This cross-sectional study utilized the data from Korean National Health and Nutrition Examination Surveys 2009-2011. The participants were categorized into 4 groups based on body composition: either sarcopenic (appendicular skeletal muscle < 23%) or not, either obese (body mass index ≥ 25.0 kg/m2) or not. The prevalence of radiographic knee OA and knee pain was calculated. The effect of hormone replacement therapy (HRT) was also evaluated. The prevalence of radiographic knee OA, knee pain, and both were all highest in the sarcopenic obese group and lowest in the control group (61.49% vs. 41.54%, 39.11% vs. 27.55%, 32.04% vs. 17.82%, all p < 0.001). Without sarcopenia, obese women showed significantly higher ratio of radiographic knee OA only (57.64% vs. 41.54%, p < 0.001). With sarcopenia, the coexistence of obesity presented higher ratio of radiographic knee OA, knee pain, and both compared to sarcopenia without obesity (61.49% vs. 41.82%, 39.11% vs. 27.61%, 32.04% vs. 17.60%, all p < 0.001). The use of HRT for more than 1 year was not associated with radiographic knee OA, knee pain, or both (p = 0.147, 0.689 and 0.649, respectively). Obesity with sarcopenia had greater effect on knee OA compared to obesity without sarcopenia. Moreover, HRT use for more than 1 year was not associated with the prevalence of knee OA. Therefore, more efforts should focus on reducing body fat and increasing muscle in postmenopausal women with knee OA.
Files in This Item:
T202203330.pdf Download
DOI
10.1038/s41598-022-17451-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hye In(김혜인) ORCID logo https://orcid.org/0000-0001-7961-5988
Seo, Seok Kyo(서석교) ORCID logo https://orcid.org/0000-0003-3404-0484
Ahn, So Hyun(안소현)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191892
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