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A Comparison of the Effectiveness of Asthma Medications on Asthma Exacerbations in Real World National Cohort

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dc.contributor.author박혜정-
dc.contributor.author이재현-
dc.contributor.author박중원-
dc.contributor.author이혜선-
dc.date.accessioned2022-12-22T03:19:23Z-
dc.date.available2022-12-22T03:19:23Z-
dc.date.issued2022-08-
dc.identifier.issn*-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/191846-
dc.description.abstractBackground: Although a wide variety of asthma medications have been developed and are used in clinical practice, there is limited evidence of their comparative effects on asthma exacerbations. Methods: We used claims data provided by the Health Insurance Review and Assessment Service. We selected subjects commencing asthma treatment between July 1, 2017 and June 30, 2018, with no change in drug regimen. The primary outcome was asthma exacerbation requiring systemic corticosteroids. Cox regression analysis was used to assess outcomes considering the exacerbation-free period. Results: Of the 254,951 asthma subjects, 107,694 subjects (42.2%) experienced asthma exacerbation. Inhaled corticosteroids (ICSs) (hazard ratio [HR], 0.378-0.508), ICS-long-acting β 2-agonist (LABAs) (HR, 0.284-0.479), long-acting muscarine antagonists (LAMAs) (HR, 0.432-0.572), leukotriene receptor antagonists (LTRAs) (HR, 0.371-0.419), and xanthines (HR, 0.326-0.482) significantly reduced the rate of first and second exacerbation of asthma (all P-values, <0.001). The clinical effectiveness of asthma medications varied according to the active ingredient (HR 0.164-0.670) and was significant for all active ingredients (all P-values, <0.001). The effectiveness of combination treatment using ICS-LABA and LTRA varied (HR, 0.159-0.670); however, all combination treatment options evaluated were effective in preventing asthma exacerbations (all P-values, <0.001). Long-term use of ICS-LABA (HR, 0.278-0.653), LTRA (HR, 0.259-0.628), and xanthines (HR, 0.351-0.783) showed consistent effectiveness (all P-values, <0.001). Conclusion: This real-world study showed that the effectiveness of asthma medications varied according to drug type, active ingredient, combination, and period of use, although effectiveness was significant in all cases studied.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherDove Medical Press-
dc.relation.isPartOfJOURNAL OF ASTHMA AND ALLERGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleA Comparison of the Effectiveness of Asthma Medications on Asthma Exacerbations in Real World National Cohort-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorHye Jung Park-
dc.contributor.googleauthorSoyoung Jeon-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorBo Yeon Kim-
dc.contributor.googleauthorYu Jin Chae-
dc.contributor.googleauthorGui Ok Kim-
dc.contributor.googleauthorJung-Won Park-
dc.contributor.googleauthorJae-Hyun Lee-
dc.identifier.doi10.2147/jaa.s379394-
dc.contributor.localIdA01769-
dc.contributor.localIdA03086-
dc.contributor.localIdA01681-
dc.contributor.localIdA03312-
dc.relation.journalcodeJ04354-
dc.identifier.eissn1178-6965-
dc.identifier.pmid36042712-
dc.subject.keywordasthma-
dc.subject.keywordcombination-
dc.subject.keyworddrug-
dc.subject.keywordexacerbation-
dc.subject.keywordmedication-
dc.subject.keywordreal-world data-
dc.contributor.alternativeNamePark, Hye Jung-
dc.contributor.affiliatedAuthor박혜정-
dc.contributor.affiliatedAuthor이재현-
dc.contributor.affiliatedAuthor박중원-
dc.contributor.affiliatedAuthor이혜선-
dc.citation.volume15-
dc.citation.startPage1155-
dc.citation.endPage1165-
dc.identifier.bibliographicCitationJOURNAL OF ASTHMA AND ALLERGY, Vol.15 : 1155-1165, 2022-08-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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