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Profile of vascular markers and CT enhancement of hyaline vascular type Castleman's disease

Authors
 Seung Hyun Park  ;  Arthur Cho  ;  Hyang Joo Ryu  ;  Honsoul Kim 
Citation
 MICROVASCULAR RESEARCH, Vol.142 : 104357, 2022-07 
Journal Title
MICROVASCULAR RESEARCH
ISSN
 0026-2862 
Issue Date
2022-07
MeSH
Castleman Disease* / diagnostic imaging ; Castleman Disease* / pathology ; Castleman Disease* / surgery ; Humans ; Hyalin ; Immunohistochemistry ; Retrospective Studies ; Tomography, X-Ray Computed
Keywords
Angiogenesis ; Castleman's disease ; Computed tomography
Abstract
Blood vessels in lymph nodes (LNs) are unique in comprising both capillaries and high endothelial venules (HEVs). Hyaline vascular type Castleman's disease accompanies robust angiogenesis, but it is unclear how the capillaries and HEVs respond. We retrospectively examined surgical specimens of hyaline vascular type unicentric Castleman's disease patients (n = 24) and control LNs (n = 9). We performed immunohistochemistry of CD 31 for capillaries and MECA-79 for HEVs and calculated their microvascular density. We measured CT enhancement as the ratio of Hounsfield Units (HUs) of the target lesion against muscle compared with microvascular density. The microvascular density of Castleman's disease specimen were (CD 31+) 169.7 ± 77.6, (MECA-79+) 203.5 ± 96.7, and the microvascular density of control LNs were (CD 31+) 80.7 ± 20.1, (MECA-79+) 67.4 ± 23.7, respectively. The microvascular density of both CD 31+ (P < 0.001) and MECA-79+ (P < 0.001) was higher in Castleman's disease. A positive correlation existed between CT HU ratio and microvascular density for both markers (CD 31: r = 0.517, P = 0.002; MECA-79: r = 0.521, P = 0.002). Intra-nodal angiogenesis of Castleman's disease involves robust proliferation of not only CD 31+ capillaries, but also MECA-79+ HVEs, which each correlated with degree of CT enhancement.
Full Text
https://www.sciencedirect.com/science/article/pii/S0026286222000474?via%3Dihub
DOI
10.1016/j.mvr.2022.104357
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Ryu, Hyang-Joo(류향주)
Cho, Arthur Eung Hyuck(조응혁) ORCID logo https://orcid.org/0000-0001-8670-2473
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191705
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