0 100

Cited 0 times in

Metabolic dysfunction-associated fatty liver disease and risk of incident chronic kidney disease: A nationwide cohort study

 Chan-Young Jung  ;  Hee Byung Koh  ;  Keun Hyung Park  ;  Young Su Joo  ;  Hyung Woo Kim  ;  Sang Hoon Ahn  ;  Jung Tak Park  ;  Seung Up Kim 
 DIABETES & METABOLISM, Vol.48(4) : 101,344, 2022-07 
Journal Title
Issue Date
Cohort Studies ; Humans ; Incidence ; Non-alcoholic Fatty Liver Disease* / complications ; Non-alcoholic Fatty Liver Disease* / epidemiology ; Renal Insufficiency, Chronic* / complications ; Renal Insufficiency, Chronic* / epidemiology ; Retrospective Studies
Chronic kidney disease ; Metabolic dysfunction-associated fatty liver disease ; Nonalcoholic fatty liver disease ; Outcomes ; Risk factors
Aims: The recently proposed metabolic dysfunction-associated fatty liver disease (MAFLD) has been suggested to better reflect the metabolic components of fatty liver disease (FLD), compared to nonalcoholic fatty liver disease (NAFLD). This study investigated whether MAFLD identifies a higher proportion of individuals at risk of developing chronic kidney disease (CKD).

Methods: 268,946 participants aged 40-64 years, who underwent National Health Insurance Service health examinations between 2009 and 2015 were included. Participants were categorized by presence of FLD, according to MAFLD or NAFLD. In participants with FLD, participants were categorized into three groups: non-metabolic risk (non-MR) NAFLD, MAFLD but not NAFLD, and overlapping FLD. Incident CKD was defined as the occurrence of eGFR < 60 mL/min/1.73m2 or proteinuria (≥ trace) on two consecutive health examinations.

Results: 73,726 (27.4%) and 88,762 (33.0%) participants had NAFLD and MAFLD, respectively. During a median follow-up of 5.1 years, CKD occurred in 8,335 (6.2/1,000 person-years) participants. Compared to non-NAFLD participants, the adjusted hazard ratio (aHR) for incident CKD was 1.33 (95% CI, 1.27-1.39; P < 0.001) for participants with NAFLD. Compared to non-MAFLD participants, the aHR for participants with MAFLD was 1.39 (95% CI, 1.33-1.46; P < 0.001). When the analysis was confined to participants with FLD, compared to non-MR NAFLD participants, the aHRs for participants with MAFLD but not NAFLD, and those with overlapping FLD were 1.18 (95% CI, 1.01-1.39; P = 0.040) and 1.36 (95% CI, 1.19-1.54; P < 0.001), respectively.

Conclusion: MAFLD identified a higher proportion of individuals at risk of developing CKD than NAFLD.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Koh, Hee Byung(고희병)
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Kim, Hyung Woo(김형우) ORCID logo https://orcid.org/0000-0002-6305-452X
Park, Keun Hyung(박근형)
Park, Jung Tak(박정탁) ORCID logo https://orcid.org/0000-0002-2325-8982
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Jung, Chan-Young(정찬영) ORCID logo https://orcid.org/0000-0002-2893-9576
Joo, Young Su(주영수) ORCID logo https://orcid.org/0000-0002-7890-0928
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.