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Higher Pulse Pressure Is Associated With Increased Risk of Cardio-cerebrovascular Disease and All-Cause Mortality: A Korean National Cohort Study
DC Field | Value | Language |
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dc.contributor.author | 김정연 | - |
dc.date.accessioned | 2022-12-22T02:33:09Z | - |
dc.date.available | 2022-12-22T02:33:09Z | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 0895-7061 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191636 | - |
dc.description.abstract | Background: This study aimed to investigate the association of pulse pressure (PP) with the cardio-cerebrovascular disease (CCVD) risk and all-cause mortality according to blood pressure level using Korean national cohort data. Methods: This study was retrospectively designed and based on the Korean National Health Insurance Service-National Health Screening Cohort. Participants aged 40-69 years at baseline were categorized into normal, elevated, stage 1, and stage 2 groups according to blood pressure. Each group was further classified into 5 groups separated by 10-mm Hg increments in PP. The primary composite outcome was defined as CCVDs and all-cause mortality. Cox proportional hazards regression models were adopted after stepwise adjustment for confounders to investigate the composite outcome. Results: During the follow-up period (median follow-up period, 12.0 years), the primary composite outcome occurred in 18,444 (15.0%) of 122,783 men and 10,096 (11.4%) of 88,550 women. After complete adjustment for confounders, in the stage 1 hypertensive men, the hazard ratio (95% confidence intervals [CIs]) of the 31-40, 41-50, 51-60, and >60 mm Hg PP groups was 1.112 (1.013-1.221), 1.035 (0.942-1.137), 1.009 (0.907-1.123), and 1.324 (1.130-1.551) in comparison with the ≤30 mm Hg PP group. In the stage 2 hypertensive men, the HRs (95% CIs) were 1.069 (0.949-1.204), 1.059 (0.940-1.192), 1.123 (0.999-1.263), and 1.202 (1.061-1.358) compared to the ≤30 mm Hg PP group. However, these associations were not significant in women. Conclusions: Hypertensive men with an increased PP have an increased risk of CCVDs and all-cause mortality. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Oxford University Press | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF HYPERTENSION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Blood Pressure / physiology | - |
dc.subject.MESH | Cerebrovascular Disorders* | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertension* / diagnosis | - |
dc.subject.MESH | Hypertension* / epidemiology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Republic of Korea / epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Higher Pulse Pressure Is Associated With Increased Risk of Cardio-cerebrovascular Disease and All-Cause Mortality: A Korean National Cohort Study | - |
dc.type | Article | - |
dc.contributor.college | College of Nursing (간호대학) | - |
dc.contributor.department | Dept. of Nursing (간호학과) | - |
dc.contributor.googleauthor | Jae-Woo Lee | - |
dc.contributor.googleauthor | Sang-Jun Shin | - |
dc.contributor.googleauthor | Joungyoun Kim | - |
dc.contributor.googleauthor | Hee-Taik Kang | - |
dc.identifier.doi | 10.1093/ajh/hpac043 | - |
dc.contributor.localId | A06089 | - |
dc.relation.journalcode | J00087 | - |
dc.identifier.eissn | 1941-7225 | - |
dc.identifier.pmid | 35363861 | - |
dc.identifier.url | https://academic.oup.com/ajh/article/35/7/647/6562376?login=true | - |
dc.subject.keyword | blood pressure | - |
dc.subject.keyword | cardiovascular disease | - |
dc.subject.keyword | cerebrovascular disease | - |
dc.subject.keyword | hypertension | - |
dc.subject.keyword | pulse pressure | - |
dc.subject.keyword | systolic blood pressure | - |
dc.contributor.alternativeName | Joungyoun Kim | - |
dc.contributor.affiliatedAuthor | 김정연 | - |
dc.citation.volume | 35 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 647 | - |
dc.citation.endPage | 655 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF HYPERTENSION, Vol.35(7) : 647-655, 2022-07 | - |
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