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Clinical Performance of Rapid and Point-of-Care Antigen Tests for SARS-CoV-2 Variants of Concern: A Living Systematic Review and Meta-Analysis

Authors
 Jimin Kim  ;  Heungsup Sung  ;  Hyukmin Lee  ;  Jae-Seok Kim  ;  Sue Shin  ;  Seri Jeong  ;  Miyoung Choi  ;  Hyeon-Jeong Lee 
Citation
 VIRUSES-BASEL, Vol.14(7) : 1479, 2022-07 
Journal Title
VIRUSES-BASEL
Issue Date
2022-07
MeSH
COVID-19* / diagnosis ; Humans ; Pandemics ; Point-of-Care Systems ; SARS-CoV-2* / genetics ; Sensitivity and Specificity
Keywords
COVID-19 ; SARS-CoV-2 ; performance ; rapid antigen test ; variant
Abstract
Rapid antigen tests (RATs) for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are widely used in the Coronavirus disease 2019 (COVID-19) pandemic caused by diverse variants. Information on the real-world performance of RATs for variants is urgently needed for decision makers. Systematic searches of the available literature and updates were conducted in PubMed, Ovid-MEDLINE, Ovid-EMBASE, CENTRAL, and KMBASE for articles evaluating the accuracy of instrument-free RATs for variants up until 14 March 2022. A bivariate random effects model was utilized to calculate pooled diagnostic values in comparison with real-time reverse transcription-polymerase chain reaction as the reference test. A total of 7562 samples from six studies were available for the meta-analysis. The overall pooled sensitivity and specificity of RATs for variants were 69.7% (95% confidence interval [CI] = 62.5% to 76.1%) and 100.0% (95% CI = 98.8% to 100.0%), respectively. When an additional 2179 samples from seven studies reporting sensitivities only were assessed, the pooled sensitivity dropped to 50.0% (95% CI = 44.0% to 55.0%). These findings suggest reassessment and monitoring of the diagnostic utility of RATs for variants, especially for the sensitivity aspect, to facilitate appropriate diagnosis and management of COVID-19 patients.
Files in This Item:
T202205380.pdf Download
DOI
10.3390/v14071479
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Hyuk Min(이혁민) ORCID logo https://orcid.org/0000-0002-8523-4126
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191630
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