0 190

Cited 13 times in

A systematic review and meta-analysis of structural and functional brain alterations in individuals with genetic and clinical high-risk for psychosis and bipolar disorder

Authors
 Licia P Luna  ;  Joaquim Radua  ;  Lydia Fortea  ;  Gisela Sugranyes  ;  Adriana Fortea  ;  Paolo Fusar-Poli  ;  Lee Smith  ;  Joseph Firth  ;  Jae Il Shin  ;  Andre R Brunoni  ;  Muhammad I Husain  ;  Muhammad O Husian  ;  Haris I Sair  ;  Walber O Mendes  ;  Luiz Ricardo A Uchoa  ;  Michael Berk  ;  Michael Maes  ;  Zafiris J Daskalakis  ;  Sophia Frangou  ;  Michele Fornaro  ;  Eduard Vieta  ;  Brendon Stubbs  ;  Marco Solmi  ;  Andre F Carvalho 
Citation
 PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, Vol.117 : 110540, 2022-07 
Journal Title
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
ISSN
 0278-5846 
Issue Date
2022-07
MeSH
Bipolar Disorder* / diagnostic imaging ; Bipolar Disorder* / genetics ; Bipolar Disorder* / pathology ; Brain / diagnostic imaging ; Brain / pathology ; Gray Matter / diagnostic imaging ; Gray Matter / pathology ; Humans ; Magnetic Resonance Imaging / methods ; Neuroimaging ; Psychotic Disorders* / diagnostic imaging ; Psychotic Disorders* / genetics ; Psychotic Disorders* / pathology
Keywords
Bipolar disorder ; Meta-analysis ; Neuroimaging ; Psychiatry ; Psychosis ; Schizophrenia
Abstract
Neuroimaging findings in people at either genetic risk or at clinical high-risk for psychosis (CHR-P) or bipolar disorder (CHR-B) remain unclear. A meta-analytic review of whole-brain voxel-based morphometry (VBM) and functional magnetic resonance imaging (fMRI) studies in individuals with genetic risk or CHR-P or CHR-B and controls identified 94 datasets (N = 7942). Notwithstanding no significant findings were observed following adjustment for multiple comparisons, several findings were noted at a more liberal threshold. Subjects at genetic risk for schizophrenia or bipolar disorder or at CHR-P exhibited lower gray matter (GM) volumes in the gyrus rectus (Hedges' g = -0.19). Genetic risk for psychosis was associated with GM reductions in the right cerebellum and left amygdala. CHR-P was associated with decreased GM volumes in the frontal superior gyrus and hypoactivation in the right precuneus, the superior frontal gyrus and the right inferior frontal gyrus. Genetic and CHR-P were associated with small structural and functional alterations involving regions implicated in psychosis. Further neuroimaging studies in individuals with genetic or CHR-B are warranted.
Full Text
https://www.sciencedirect.com/science/article/pii/S027858462200032X?via%3Dihub
DOI
10.1016/j.pnpbp.2022.110540
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191628
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links