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Prognostic significance of three endothelial nitric oxide synthase (eNOS) polymorphisms and metabolic syndrome (MetS) in patients with colorectal cancer

Authors
 Eun Ju Ko  ;  Eo Jin Kim  ;  Hye Jung Cho  ;  Jisu Oh  ;  Han Sung Park  ;  Chang Soo Ryu  ;  Jung Oh Kim  ;  Hak Hoon Jun  ;  So Young Chong  ;  Jong Woo Kim  ;  Nam Keun Kim 
Citation
 GENES & GENOMICS, Vol.44(6) : 659-670, 2022-06 
Journal Title
GENES & GENOMICS
ISSN
 1976-9571 
Issue Date
2022-06
MeSH
Colorectal Neoplasms* / complications ; Colorectal Neoplasms* / genetics ; Humans ; Metabolic Syndrome* / complications ; Metabolic Syndrome* / genetics ; Nitric Oxide Synthase Type III / genetics ; Polymorphism, Genetic ; Prognosis
Keywords
Colorectal cancer ; Metabolic syndrome ; Nitric oxide ; Polymorphism ; Susceptibility ; eNOS
Abstract
Background: Polymorphisms of endothelial nitric oxide synthases (eNOS) have been associated with cancer susceptibility. Also, metabolic syndrome is associated with cancer malignancy. However, the effect of eNOS polymorphisms and metabolic syndrome on colorectal cancer (CRC) prognosis remains unclear.

Objective: To investigated whether three genetic polymorphisms (- 786 T > C rs2070744, 4a4b rs869109213, and 894G > T rs1799983) in the eNOS and metabolic syndrome (MetS) were associated with CRC patient survival.

Methods: We genotyped three polymorphisms of eNOS (- 786 T > C, 4a4b, and 894G > T) in 312 CRC cases from the Korean population by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.

Results: Although the three eNOS polymorphisms were not causative of MetS, the TT genotype of the 894G > T polymorphism was associated with a worse survival rate compared with the GG genotype in the CRC group with MetS than in the CRC group without MetS (5-years survival; adjusted HR = 54.777; 95% CI 5.073-591.487 and RFS; adjusted HR = 14.909; 95% CI 1.571-141.528).

Conclusions: The eNOS polymorphisms were not associated with metabolic syndrome prevalence in CRC patients. However, our findings suggest that the eNOS 894G > T polymorphism with MetS was associated with poor clinical outcomes.
Full Text
https://link.springer.com/article/10.1007/s13258-022-01246-9
DOI
10.1007/s13258-022-01246-9
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Oh, Jisu(오지수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191555
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