Cited 4 times in
Longitudinal association of thyroid-stimulating immunoglobulin levels with clinical characteristics in thyroid eye disease
DC Field | Value | Language |
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dc.contributor.author | 고재상 | - |
dc.contributor.author | 윤진숙 | - |
dc.date.accessioned | 2022-12-22T02:19:04Z | - |
dc.date.available | 2022-12-22T02:19:04Z | - |
dc.date.issued | 2022-06 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191528 | - |
dc.description.abstract | Objectives: The clinical course of thyroid eye disease (TED) is heterogeneous and predicting patients who may develop the severe sequelae of the disease is difficult. In this study, we evaluated the longitudinal association between changes in serum thyroid-stimulating hormone (TSH) receptor antibody (TRAb) levels and course of disease activity and severity over time. Design: This was a multicentre, prospective, observational study. Setting: Fifteen tertiary care oculoplastic service centres in Korea. Participants: Seventy-six patients with newly diagnosed TED were included and followed up for 12 months. Methods: We evaluated clinical characteristics and serum TRAb levels at baseline, 6 and 12 months of TED diagnosis. Additionally, we analysed longitudinal associations between the serum TRAb levels and clinical activity score (CAS), no signs or symptoms, only signs, soft tissue involvement, proptosis, extraocular muscle involvement, corneal involvement, sight loss (NOSPECS) score and proptosis. Results: Thyroid-stimulating immunoglobulin (TSI) and TSH-binding inhibitory immunoglobulin (TBII) levels decreased during the 1-year follow-up, whereas disease activity measured using CAS decreased mainly in the first 6 months. Disease severity measured using NOSPECS score and proptosis remained unchanged. Moreover, inter-person differences in TBII levels were associated with CAS, NOSPECS score and proptosis over time, whereas inter-person differences in TSI levels were associated with NOSPECS score. Subgroup analysis of patients with a baseline CAS≥4 demonstrated that within-person changes in TSI levels affected the CAS and NOSPECS score. Conclusions: Follow-up measurement of serum TSI and TBII levels may help evaluate TED prognosis and enable accurate clinical decision-making. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | BMJ Publishing Group Ltd | - |
dc.relation.isPartOf | BMJ OPEN | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Autoantibodies | - |
dc.subject.MESH | Graves Ophthalmopathy* / diagnosis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoglobulins, Thyroid-Stimulating | - |
dc.subject.MESH | Immunologic Tests | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Receptors, Thyrotropin | - |
dc.title | Longitudinal association of thyroid-stimulating immunoglobulin levels with clinical characteristics in thyroid eye disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학교실) | - |
dc.contributor.googleauthor | JaeSang Ko | - |
dc.contributor.googleauthor | Koung Hoon Kook | - |
dc.contributor.googleauthor | Jin Sook Yoon | - |
dc.contributor.googleauthor | Kyung In Woo | - |
dc.contributor.googleauthor | Jae Wook Yang | - |
dc.identifier.doi | 10.1136/bmjopen-2021-050337 | - |
dc.contributor.localId | A04876 | - |
dc.contributor.localId | A02611 | - |
dc.relation.journalcode | J00380 | - |
dc.identifier.eissn | 2044-6055 | - |
dc.identifier.pmid | 35728893 | - |
dc.subject.keyword | oculoplastics | - |
dc.subject.keyword | orbital and lacrimal disorders | - |
dc.subject.keyword | thyroid disease | - |
dc.contributor.alternativeName | Ko, Jaesang | - |
dc.contributor.affiliatedAuthor | 고재상 | - |
dc.contributor.affiliatedAuthor | 윤진숙 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | e050337 | - |
dc.identifier.bibliographicCitation | BMJ OPEN, Vol.12(6) : e050337, 2022-06 | - |
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