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Association between autism spectrum disorder and diabetes: systematic review and meta-analysis

Authors
 Samuele Cortese  ;  Alessandra Gabellone  ;  Lucia Marzulli  ;  Iciar Iturmendi-Sabater  ;  Diego de La Chica-Duarte  ;  Isabella M Piqué  ;  Marco Solmi  ;  Jae Il Shin  ;  Lucia Margari  ;  Gonzalo Arrondo 
Citation
 NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, Vol.136 : 104592, 2022-05 
Journal Title
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
ISSN
 0149-7634 
Issue Date
2022-05
MeSH
Autism Spectrum Disorder* / complications ; Child ; Diabetes Mellitus, Type 2* / complications ; Humans
Keywords
Autism ; Diabetes ; Meta-analysis
Abstract
There is mixed evidence on the link between autism spectrum disorder (ASD) and diabetes. We conducted the first systematic review/meta-analysis on their association. Based on a pre-registered protocol (PROSPERO: CRD42021261114), we searched Pubmed, Ovid, and Web of Science databases up to 6 December 2021, with no language/type of document restrictions. We assessed study quality using the Newcastle-Ottawa Scale (NOS). We included 24 studies (total: 3427,773 individuals; 237,529 with ASD and 92,832 with diabetes) in the systematic review and 20 in the meta-analysis (mean stars number on the NOS: 5.89/10). There was a significant association, albeit characterized by significant heterogeneity, when pooling unadjusted OR (1.535, 95% CI = 1.109-2.126), which remained significant when restricting the analysis to children and type 2 diabetes, but became non-significant when considering adjusted ORs (OR: 1.528, 95% CI = 0.954-2.448). No significant prospective association was found (n = 2) on diabetes predicting ASD (HR: 1.232, 0.826-11.837). Therefore, the association between ASD and diabetes is likely confounded by demographic and clinical factors that should be systematically investigated in future studies.
Files in This Item:
T202205450.pdf Download
DOI
10.1016/j.neubiorev.2022.104592
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191452
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