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Sprayable nanomicelle hydrogels and inflammatory bowel disease patient cell chips for development of intestinal lesion-specific therapy

DC Field Value Language
dc.contributor.author고홍-
dc.contributor.author성학준-
dc.contributor.author윤효진-
dc.contributor.author구철룡-
dc.contributor.author정영신-
dc.contributor.author신영민-
dc.date.accessioned2022-12-22T01:38:01Z-
dc.date.available2022-12-22T01:38:01Z-
dc.date.issued2022-03-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/191276-
dc.description.abstractAll-in-one treatments represent a paradigm shift in future medicine. For example, inflammatory bowel disease (IBD) is mainly diagnosed by endoscopy, which could be applied for not only on-site monitoring but also the intestinal lesion-targeted spray of injectable hydrogels. Furthermore, molecular conjugation to the hydrogels would program both lesion-specific adhesion and drug-free therapy. This study validated this concept of all-in-one treatment by first utilizing a well-known injectable hydrogel that underwent efficient solution-to-gel transition and nanomicelle formation as a translatable component. These properties enabled spraying of the hydrogel onto the intestinal walls during endoscopy. Next, peptide conjugation to the hydrogel guided endoscopic monitoring of IBD progress upon adhesive gelation with subsequent moisturization of inflammatory lesions, specifically by nanomicelles. The peptide was designed to mimic the major component that mediates intestinal interaction with Bacillus subtilis flagellin during IBD initiation. Hence, the peptide-guided efficient adhesion of the hydrogel nanomicelles onto Toll-like receptor 5 (TLR5) as the main target of flagellin binding and Notch-1. The peptide binding potently suppressed inflammatory signaling without drug loading, where TLR5 and Notch-1 operated collaboratively through downstream actions of tumor necrosis factor-alpha. The results were produced using a human colorectal cell line, clinical IBD patient cells, gut-on-a-chip, a mouse IBD model, and pig experiments to validate the translational utility.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKe Ai Publishing-
dc.relation.isPartOfBIOACTIVE MATERIALS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleSprayable nanomicelle hydrogels and inflammatory bowel disease patient cell chips for development of intestinal lesion-specific therapy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학교실)-
dc.contributor.googleauthorHyo-Jin Yoon-
dc.contributor.googleauthorSonghyun Lee-
dc.contributor.googleauthorTae Young Kim-
dc.contributor.googleauthorSeung Eun Yu-
dc.contributor.googleauthorHye-Seon Kim-
dc.contributor.googleauthorYoung Shin Chung-
dc.contributor.googleauthorSeyong Chung-
dc.contributor.googleauthorSuji Park-
dc.contributor.googleauthorYong Cheol Shin-
dc.contributor.googleauthorEun Kyung Wang-
dc.contributor.googleauthorJihye Noh-
dc.contributor.googleauthorHyun Jung Kim-
dc.contributor.googleauthorCheol Ryong Ku-
dc.contributor.googleauthorHong Koh-
dc.contributor.googleauthorChang-Soo Kim-
dc.contributor.googleauthorJoon-Sang Park-
dc.contributor.googleauthorYoung Min Shin-
dc.contributor.googleauthorHak-Joon Sung-
dc.identifier.doi10.1016/j.bioactmat.2022.03.031-
dc.contributor.localIdA00156-
dc.contributor.localIdA01958-
dc.contributor.localIdA06078-
dc.contributor.localIdA00201-
dc.contributor.localIdA04849-
dc.contributor.localIdA05925-
dc.relation.journalcodeJ04181-
dc.identifier.eissn2452-199X-
dc.identifier.pmid35415304-
dc.subject.keywordAll-in-one treatment-
dc.subject.keywordDLS, dynamic light scattering-
dc.subject.keywordDSS, dextran sodium sulfate-
dc.subject.keywordHPLC, high-performance liquid chromatography-
dc.subject.keywordIBD, inflammatory bowel disease-
dc.subject.keywordInflammatory bowel disease-
dc.subject.keywordInjectable hydrogel-
dc.subject.keywordNanomicelle-
dc.subject.keywordP(CL), poly(caprolactone)-
dc.subject.keywordPe, peptide-
dc.subject.keywordPeptide display-
dc.subject.keywordR&D, research and development-
dc.subject.keywordSEM, scanning electron microscopy-
dc.subject.keywordTEER, transepithelial electrical resistance-
dc.subject.keywordTEM, transmission electron microscopy-
dc.subject.keywordTLR5, Toll-like receptor 5-
dc.subject.keywordTNF-α, tumor necrosis factor-alpha-
dc.subject.keywordTheranostic-
dc.subject.keywordmPEG, methoxy poly (ethylene glycol).-
dc.contributor.alternativeNameKoh, Hong-
dc.contributor.affiliatedAuthor고홍-
dc.contributor.affiliatedAuthor성학준-
dc.contributor.affiliatedAuthor윤효진-
dc.contributor.affiliatedAuthor구철룡-
dc.contributor.affiliatedAuthor정영신-
dc.contributor.affiliatedAuthor신영민-
dc.citation.volume18-
dc.citation.startPage433-
dc.citation.endPage445-
dc.identifier.bibliographicCitationBIOACTIVE MATERIALS, Vol.18 : 433-445, 2022-03-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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