Cited 37 times in
Maternal inflammation and its ramifications on fetal neurodevelopment
DC Field | Value | Language |
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dc.contributor.author | 권호근 | - |
dc.date.accessioned | 2022-12-22T01:35:34Z | - |
dc.date.available | 2022-12-22T01:35:34Z | - |
dc.date.issued | 2022-03 | - |
dc.identifier.issn | 1471-4906 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191266 | - |
dc.description.abstract | Exposure to heightened inflammation in pregnancy caused by infections or other inflammatory insults has been associated with the onset of neurodevelopmental and psychiatric disorders in children. Rodent models have provided unique insights into how this maternal immune activation (MIA) disrupts brain development. Here, we discuss the key immune factors involved, highlight recent advances in determining the molecular and cellular pathways of MIA, and review how the maternal immune system affects fetal development. We also examine the roles of microbiomes in shaping maternal immune function and the development of autism-like phenotypes. A comprehensive understanding of the gut bacteria-immune-neuro interaction in MIA is essential for developing diagnostic and therapeutic measures for high-risk pregnant women and identifying targets for treating inflammation-induced neurodevelopmental disorders | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science Ltd. | - |
dc.relation.isPartOf | TRENDS IN IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immune System | - |
dc.subject.MESH | Inflammation / immunology | - |
dc.subject.MESH | Microbiota* | - |
dc.subject.MESH | Pregnancy | - |
dc.subject.MESH | Prenatal Exposure Delayed Effects* / chemically induced | - |
dc.subject.MESH | Prenatal Exposure Delayed Effects* / immunology | - |
dc.title | Maternal inflammation and its ramifications on fetal neurodevelopment | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | Ho-Keun Kwon | - |
dc.contributor.googleauthor | Gloria B Choi | - |
dc.contributor.googleauthor | Jun R Huh | - |
dc.identifier.doi | 10.1016/j.it.2022.01.007 | - |
dc.contributor.localId | A05782 | - |
dc.relation.journalcode | J03853 | - |
dc.identifier.eissn | 1471-4981 | - |
dc.identifier.pmid | 35131181 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1471490622000072?via%3Dihub | - |
dc.contributor.alternativeName | Kwon, Ho-Keun | - |
dc.contributor.affiliatedAuthor | 권호근 | - |
dc.citation.volume | 43 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 230 | - |
dc.citation.endPage | 244 | - |
dc.identifier.bibliographicCitation | TRENDS IN IMMUNOLOGY, Vol.43(3) : 230-244, 2022-03 | - |
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