121 225

Cited 11 times in

Mapping brain structural differences and neuroreceptor correlates in Parkinson's disease visual hallucinations

Authors
 Miriam Vignando  ;  Dominic Ffytche  ;  Simon J G Lewis  ;  Phil Hyu Lee  ;  Seok Jong Chung  ;  Rimona S Weil  ;  Michele T Hu  ;  Clare E Mackay  ;  Ludovica Griffanti  ;  Delphine Pins  ;  Kathy Dujardin  ;  Renaud Jardri  ;  John-Paul Taylor  ;  Michael Firbank  ;  Grainne McAlonan  ;  Henry K F Mak  ;  Shu Leong Ho  ;  Mitul A Mehta 
Citation
 NATURE COMMUNICATIONS, Vol.13(1) : 519, 2022-01 
Journal Title
NATURE COMMUNICATIONS
Issue Date
2022-01
MeSH
Aged ; Bayes Theorem ; Brain / diagnostic imaging ; Brain Mapping* ; Cerebral Cortex ; Female ; Hallucinations* ; Hippocampus ; Humans ; Male ; Middle Aged ; Parkinson Disease* ; Sensory Receptor Cells*
Abstract
Parkinson's psychosis (PDP) describes a spectrum of symptoms that may arise in Parkinson's disease (PD) including visual hallucinations (VH). Imaging studies investigating the neural correlates of PDP have been inconsistent in their findings, due to differences in study design and limitations of scale. Here we use empirical Bayes harmonisation to pool together structural imaging data from multiple research groups into a large-scale mega-analysis, allowing us to identify cortical regions and networks involved in VH and their relation to receptor binding. Differences of morphometrics analysed show a wider cortical involvement underlying VH than previously recognised, including primary visual cortex and surrounding regions, and the hippocampus, independent of its role in cognitive decline. Structural covariance analyses point to the involvement of the attentional control networks in PD-VH, while associations with receptor density maps suggest neurotransmitter loss may be linked to the cortical changes.
Files in This Item:
T202204411.pdf Download
DOI
10.1038/s41467-022-28087-0
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Chung, Seok Jong(정석종) ORCID logo https://orcid.org/0000-0001-6086-3199
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191200
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links