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Association of Body Weight Variability With Progression of Coronary Artery Calcification in Patients With Predialysis Chronic Kidney Disease

Authors
 Sang Heon Suh  ;  Tae Ryom Oh  ;  Hong Sang Choi  ;  Chang Seong Kim  ;  Eun Hui Bae  ;  Kook-Hwan Oh  ;  Kyu-Beck Lee  ;  Seung Hyeok Han  ;  Suah Sung  ;  Seong Kwon Ma  ;  Soo Wan Kim 
Citation
 FRONTIERS IN CARDIOVASCULAR MEDICINE, Vol.8 : 794957, 2022-01 
Journal Title
FRONTIERS IN CARDIOVASCULAR MEDICINE
Issue Date
2022-01
Keywords
body weigh variability ; cardiovascular disease ; cardiovascular event ; chronic kidney disease ; coronary artery calcification
Abstract
Background: We investigated whether high body weight variability (BWV) is associated with a higher prevalence of coronary artery calcification (CAC) or more rapid progression of CAC in patients with predialysis chronic kidney disease (CKD).

Methods: A total of 1,162 subjects from a nationwide prospective cohort of predialysis CKD were analyzed. The subjects were divided into the tertile (T1, T2, and T3) by BWV. CAC was assessed at the baseline and a 4-year follow-up by CT scan. Rapid progression of coronary artery calcification was defined as an increase in coronary artery calcium score (CACS) more than 200 Agatston units during a 4-year follow-up.

Results: One-way ANOVA revealed that CACS change during the follow-up period is significantly higher in the subjects with high BWV, although CACS at the baseline and 4-year follow-up was not different among the tertile groups by BWV. Logistic regression analysis revealed that compared to low BWV (T1), both moderate (T2, adjusted odds ratio (OR) 2.118, 95% CI 1.075-4.175) and high (T3, adjusted OR 2.602, 95% CI 1.304-5.191) BWV was associated with significantly increased risk of rapid progression of CAC. Importantly, the association between BWV and progression of CAC remained robust even among the subjects without significant BW gain or loss during follow-up periods (T2, adjusted OR 2.007, 95% CI 1.011-3.984; T3, adjusted OR 2.054, 95% CI 1.003-4.207).

Conclusion: High BWV is independently associated with rapid progression of CAC in patients with predialysis CKD.
Files in This Item:
T202205152.pdf Download
DOI
10.3389/fcvm.2021.794957
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Han, Seung Hyeok(한승혁) ORCID logo https://orcid.org/0000-0001-7923-5635
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191183
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