3 203

Cited 17 times in

Effects of steroid therapy in patients with severe fever with Thrombocytopenia syndrome: A multicenter clinical cohort study

Authors
 Sook In Jung  ;  Ye Eun Kim  ;  Na Ra Yun  ;  Choon-Mee Kim  ;  Dong-Min Kim  ;  Mi Ah Han  ;  Uh Jin Kim  ;  Seong Eun Kim  ;  Jieun Kim  ;  Seong Yeol Ryu  ;  Hyun Ah Kim  ;  Jian Hur  ;  Young Keun Kim  ;  Hye Won Jeong  ;  Jung Yeon Heo  ;  Dong Sik Jung  ;  Hyungdon Lee  ;  Kyungmin Huh  ;  Yee Gyung Kwak  ;  Sujin Lee  ;  Seungjin Lim  ;  Sun Hee Lee  ;  Sun Hee Park  ;  Joon-Sup Yeom  ;  Shin-Woo Kim  ;  In-Gyu Bae  ;  Juhyung Lee  ;  Eu Suk Kim  ;  Jun-Won Seo 
Citation
 PLOS NEGLECTED TROPICAL DISEASES, Vol.15(2) : e0009128, 2021-02 
Journal Title
PLOS NEGLECTED TROPICAL DISEASES
ISSN
 1935-2727 
Issue Date
2021-02
MeSH
Aged ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Phlebovirus ; Retrospective Studies ; Risk Factors ; Severe Fever with Thrombocytopenia Syndrome / diagnosis* ; Severe Fever with Thrombocytopenia Syndrome / epidemiology* ; Severe Fever with Thrombocytopenia Syndrome / therapy* ; Steroids / therapeutic use* ; Survival Analysis ; Tick-Borne Diseases
Abstract
Background: Severe fever with thrombocytopenia syndrome (SFTS) is an acute, febrile, and potentially fatal tick-borne disease caused by the SFTS Phlebovirus. Here, we evaluated the effects of steroid therapy in Korean patients with SFTS.

Methods: A retrospective study was performed in a multicenter SFTS clinical cohort from 13 Korean university hospitals between 2013 and 2017. We performed survival analysis using propensity score matching of 142 patients with SFTS diagnosed by genetic or antibody tests.

Results: Overall fatality rate was 23.2%, with 39.7% among 58 patients who underwent steroid therapy. Complications were observed in 37/58 (63.8%) and 25/83 (30.1%) patients in the steroid and non-steroid groups, respectively (P < .001). Survival analysis after propensity score matching showed a significant difference in mean 30-day survival time between the non-steroid and steroid groups in patients with a mild condition [Acute Physiology and Chronic Health Evaluation II (APACHE II) score <14; 29.2 (95% CI 27.70-30.73] vs. 24.9 (95% CI 21.21-28.53], P = .022]. Survival times for the early steroid (≤5 days from the start of therapy after symptom onset), late steroid (>5 days), and non-steroid groups, were 18.4, 22.4, and 27.3 days, respectively (P = .005).

Conclusions: After steroid therapy, an increase in complications was observed among patients with SFTS. Steroid therapy should be used with caution, considering the possible negative effects of steroid therapy within 5 days of symptom onset or in patients with mild disease (APACHE II score <14).
Files in This Item:
T9992022448.pdf Download
DOI
10.1371/journal.pntd.0009128
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Yeom, Joon Sup(염준섭) ORCID logo https://orcid.org/0000-0001-8940-7170
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191041
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links