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Influenza Vaccine Effectiveness in Children at the Emergency Department during the 2018-2019 Season: the First Season School-aged Children Were Included in the Korean Influenza National Immunization Program

Authors
 Yoonsun Yoon  ;  Joon Sik Choi  ;  MiRan Park  ;  Hyun Cho  ;  Minsu Park  ;  Hee Jae Huh  ;  Yae Jean Kim  ;  Meong Hi Son 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.36(10), 2021-03 
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
 1011-8934 
Issue Date
2021-03
MeSH
Adolescent ; Child ; Emergency Service, Hospital / statistics & numerical data* ; Female ; Hospitalization / statistics & numerical data ; Humans ; Immunization Programs / organization & administration* ; Influenza A Virus, H1N1 Subtype / immunology ; Influenza A Virus, H3N2 Subtype / immunology ; Influenza B virus / immunology ; Influenza Vaccines / immunology ; Influenza Vaccines / therapeutic use* ; Influenza, Human / epidemiology ; Influenza, Human / prevention & control* ; Influenza, Human / virology ; Male ; Republic of Korea / epidemiology ; Retrospective Studies ; Seasons ; Vaccination / statistics & numerical data*
Keywords
Children ; Influenza ; National Immunization Program ; Vaccine Effectiveness
Abstract
Background: For the 2018-2019 season, the national influenza immunization program expanded to cover children aged from 6 months to 12 years in Korea. This study aimed to analyze vaccine effectiveness (VE) against influenza in children visiting the pediatric emergency room at a tertiary hospital during the 2018-2019 season.

Methods: Patients tested for influenza antigens from October 1st 2018 to May 31st 2019 at the pediatric emergency room of Samsung Medical Center were included. Patients' influenza antigen test results, influenza vaccination history, and underlying medical conditions were reviewed retrospectively. VE was estimated from the test-negative design study.

Results: Among the 2,901 visits with influenza test results 1,692 visits of 1,417 patients were included for analysis. Among these 1,417 patients, 285 (20.1%) were positive (influenza A, n = 211, 74.0%; influenza B, n = 74, 26.0%). The VE in all patients was 36.4% (95% confidence interval [CI], 13.9 to 53.1). The VE for influenza A was 37.6% (95% CI, 12.6 to 55.5) and VE for influenza B was 24.0% (?38.5 to 58.3). The VE in the age group 6 months to 12 years was significant with a value of 35.6% (95% CI, 10.5 to 53.7); it was not statistically significant in the age group 13 to 18 years. In a multivariate logistic regression model, patients who received an influenza vaccination were less likely to get influenza infection (OR, 0.6; 95% CI, 0.4 to 0.8; P = 0.001), with significant confounding factors such as age group 13 to 18 years (OR, 0.5; 95% CI, 0.3 to 0.8; P = 0.003) and underlying hematology-oncology disease (OR, 0.3; 95% CI, 0.1 to 0.6; P = 0.002).

Conclusion: We report moderate effectiveness of influenza vaccination in previously healthy children aged from 6 months to 12 years in the 2018-2019 season.
DOI
10.3346/jkms.2021.36.e71
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Choi, Joon Sik(최준식)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191019
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