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Particulate matter (PM10) as a newly identified environmental risk factor for acute gout flares: A time-series study

Authors
 Hee Jung Ryu  ;  Mi Ryoung Seo  ;  Hyo Jin Choi  ;  Jaelim Cho  ;  Han Joo Baek 
Citation
 JOINT BONE SPINE, Vol.88(2) : 105108, 2021-03 
Journal Title
JOINT BONE SPINE
ISSN
 1297-319X 
Issue Date
2021-03
MeSH
Air Pollutants* ; Air Pollution* ; Gout* / diagnosis ; Gout* / epidemiology ; Humans ; Male ; Particulate Matter / adverse effects ; Republic of Korea / epidemiology ; Risk Factors ; Symptom Flare Up
Keywords
Air pollution ; Gout ; Particulate matter ; Risk factor
Abstract
Objectives: This study aimed to investigate the effect of short-term exposure to ambient particulate matter less than 10μm in diameter (PM10) on occurrence of acute gout flares in the general population and identify susceptible groups accordingly.

Methods: The data of emergency department (ED) cases with acute gout flare in Incheon city, Korea between January 1st 2008 and December 31st 2015 were collected from the National Health Insurance Service claims data. The levels of PM10 and meterological measurements were provided by the Ministry of Environment and the National Meterological Office, respectively. To estimate the risk of daily ED visits due to acute gout flare, these time-series data set were analyzed using generalized additive models with Poisson distribution, including daily average PM10 level, temperature, relative humidity, day of the week, national holiday, season, and date.

Results: The risk of daily ED visits for acute gout flares per interquartile range increment of the average daily PM10 levels significantly increased in the cumulative lag 0-7 model (relative risk, 1.018; 95% confidence interval, 1.008-1.027, P<0.001). In particular, men aged≥40 years and those with a history of diabetes mellitus or gout were significantly at a high risk of acute gout flares by subgroup analysis.

Conclusions: Our time-series study demonstrated a modest, but significant effect of short-term exposure to PM10 on ED visits for acute gout flares. Ambient PM10 may be a newly identified environmental risk factor for acute gout flares.
Full Text
https://www.sciencedirect.com/science/article/pii/S1297319X20302153
DOI
10.1016/j.jbspin.2020.105108
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Cho, Jae Lim(조재림)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/191000
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