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코로나19 약물치료의 최신지견

Other Titles
 Current advances in pharmacological treatments for patients with COVID-19 
Authors
 Sun Bean Kim  ;  Joon-Sup Yeom 
Citation
 JOURNAL OF THE KOREAN MEDICAL ASSOCIATION, Vol.64(5) : 375-385, 2021-05 
Journal Title
JOURNAL OF THE KOREAN MEDICAL ASSOCIATION(대한의사협회지)
ISSN
 1975-8456 
Issue Date
2021-05
Keywords
COVID-19 ; Coronavirus infections ; Antiviral agents ; Immunomodulators ; Monoclonal antibodies
Abstract
Since the coronavirus disease 2019 (COVID-19) outbreak, more than 150 million people in over 200 countries have been infected, with over 3 million people dying due to it, as of May 1, 2021. Many researchers are working continuously to find effective drug treatments for COVID-19; however, the optimal treatment approach remains unclear. In this article, current advances in pharmacological treatments for patients with COVID-19 are discussed. Data obtained from recent studies indicate a mortality benefit with the administration of dexamethasone or adjunctive tocilizumab and potential clinical benefits with remdesivir (with or without baricitinib). Several monoclonal antibodies against severe acute respiratory syndrome coronavirus 2 have been developed. The US Food and Drug Administration issued two emergency use authorizations: one for bamlanivimab/etesevimab and another for casirivimab/imdevimab for patients with mild to moderate COVID-19, at high risk of progression to severe disease and/or hospitalization. The pathogenesis of COVID-19 indicates that antiviral treatments would be most beneficial in the early phase of the infection that is primarily driven by replication of severe acute respiratory syndrome coronavirus 2, whereas immunosuppressive/anti-inflammatory therapies are likely to be more beneficial during the late phase of the infection, when the disease is driven by an exaggerated immune/inflammatory response to the virus that causes tissue damage.
DOI
10.5124/jkma.2021.64.5.375
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Yeom, Joon Sup(염준섭) ORCID logo https://orcid.org/0000-0001-8940-7170
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190932
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