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Broad-Spectrum Antibiotic Regimen Affects Survival in Patients Receiving Nivolumab for Non-Small Cell Lung Cancer

Authors
 Min Jung Geum  ;  Chungsoo Kim  ;  Ji Eun Kang  ;  Jae Hee Choi  ;  Jae Song Kim  ;  Eun Sun Son  ;  Sun Min Lim  ;  Sandy Jeong Rhie 
Citation
 PHARMACEUTICALS, Vol.14(5) : 445, 2021-05 
Journal Title
PHARMACEUTICALS
ISSN
 1424-8247 
Issue Date
2021-05
Keywords
antibiotic-induced dysbiosis ; days of therapy ; defined daily dose ; nivolumab ; non-small cell lung cancer ; overall survival
Abstract
Antibiotic-induced dysbiosis may affect the efficacy of immune checkpoint inhibitors. We investigated the impact of antibiotics on the clinical outcomes of nivolumab in patients with non-small cell lung cancer (NSCLC). Patients who received nivolumab for NSCLC between July 2015 and June 2018 and who were followed up until June 2020 were included in a retrospective cohort analysis. Of 140 eligible patients, 70 were on antibiotics. Overall survival (OS) was shorter in patients on antibiotics (ABX) compared to those not on antibiotics (NoABX) (p = 0.014). OS was negatively associated with piperacillin/tazobactam (PTZ) (HR = 3.31, 95% CI: 1.77-6.18), days of therapy (DOT) ≥ 2 weeks (HR = 2.56, 95% CI: 1.30-5.22) and DOT of PTZ. The defined daily dose (DDD) in PTZ (r = 0.27) and glycopeptides (r = 0.21) showed weak correlations with mortality. There was no difference in progression-free survival (PFS) between ABX and NoABX; however, PFS was negatively associated with the antibiotic class PTZ and DOT of PTZ. Therefore, the use of a broad-spectrum antibiotic, such as PTZ, the long-term use of antibiotics more than 2 weeks in total and the large amount of defined daily dose of specific antibiotics were associated with decreased survival in patients receiving nivolumab for NSCLC.
DOI
10.3390/ph14050445
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lim, Sun Min(임선민)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190920
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