Cited 12 times in
Peripapillary vessel parameters and mean ocular perfusion pressure in young healthy eyes: OCT angiography study
DC Field | Value | Language |
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dc.contributor.author | 이동현 | - |
dc.date.accessioned | 2022-11-24T00:41:34Z | - |
dc.date.available | 2022-11-24T00:41:34Z | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 0007-1161 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190905 | - |
dc.description.abstract | Background: To investigate the relationship between estimated mean ocular perfusion pressure (MOPP) and peripapillary perfusion density (PD) or vessel density (VD) as measured by spectral-domain optical coherence tomography angiography (OCTA) in young healthy eyes. Methods: 132 healthy participants (264 eyes) under 45 years of age underwent optic disc OCTA scan sized 3×3 mm to acquire PD and VD in the superficial vascular complex (SVC). Optic nerve head (ONH) parameters including retinal nerve fibre layer (RNFL) thickness, rim area and disc area were measured. MOPP was estimated from systemic blood pressure and intraocular pressure (IOP). A linear mixed model was used to find the systemic and ocular factors associated with PD and VD. Results: The average age of the subjects was 25.8±6.5 years. PD and VD showed a significant correlation with RNFL thickness (r=0.224, p<0.001 and r=0.214, p<0.001, respectively), but with MOPP, the correlation was only marginally significant (r=0.105, p=0.09 and r=0.112, p=0.07, respectively). After controlling for confounding factors, including age, sex, IOP, central corneal thickness, axial length and OCTA signal strength, PD and VD were significantly associated with ONH parameters (all p<0.05) but not with estimated MOPP (all p>0.05). Conclusion: PD and VD in the SVC were significantly associated with ONH parameters while showing no association with estimated MOPP. OCTA-derived VD may not represent perfusion pressure, but is rather more dependent on peripapillary structure. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | BMJ Pub. Group | - |
dc.relation.isPartOf | BRITISH JOURNAL OF OPHTHALMOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorescein Angiography / methods* | - |
dc.subject.MESH | Fundus Oculi | - |
dc.subject.MESH | Glaucoma, Open-Angle / diagnosis | - |
dc.subject.MESH | Glaucoma, Open-Angle / physiopathology | - |
dc.subject.MESH | Healthy Volunteers | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intraocular Pressure / physiology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Nerve Fibers / pathology | - |
dc.subject.MESH | Optic Disk / blood supply* | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Retinal Ganglion Cells / pathology* | - |
dc.subject.MESH | Retinal Vessels / diagnostic imaging | - |
dc.subject.MESH | Retinal Vessels / physiopathology* | - |
dc.subject.MESH | Tomography, Optical Coherence / methods* | - |
dc.subject.MESH | Tonometry, Ocular | - |
dc.subject.MESH | Visual Fields* | - |
dc.subject.MESH | Young Adult | - |
dc.title | Peripapillary vessel parameters and mean ocular perfusion pressure in young healthy eyes: OCT angiography study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학교실) | - |
dc.contributor.googleauthor | Young In Yun | - |
dc.contributor.googleauthor | Yong Woo Kim | - |
dc.contributor.googleauthor | Hyung Bin Lim | - |
dc.contributor.googleauthor | Dong Hyun Lee | - |
dc.contributor.googleauthor | Ji Hong Kim | - |
dc.contributor.googleauthor | Baek-Lok Oh | - |
dc.contributor.googleauthor | Jin Wook Jeoung | - |
dc.contributor.googleauthor | Ki Ho Park | - |
dc.identifier.doi | 10.1136/bjophthalmol-2020-316222 | - |
dc.contributor.localId | A04779 | - |
dc.relation.journalcode | J00412 | - |
dc.identifier.eissn | 1468-2079 | - |
dc.identifier.pmid | 32703786 | - |
dc.identifier.url | https://bjo.bmj.com/content/105/6/862.long | - |
dc.subject.keyword | Imaging | - |
dc.subject.keyword | Optic nerve | - |
dc.contributor.alternativeName | Lee, Dong Hyun | - |
dc.contributor.affiliatedAuthor | 이동현 | - |
dc.citation.volume | 105 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 862 | - |
dc.citation.endPage | 868 | - |
dc.identifier.bibliographicCitation | BRITISH JOURNAL OF OPHTHALMOLOGY, Vol.105(6) : 862-868, 2021-06 | - |
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