Cited 3 times in
Improvement in Near Vision Following Silodosin Treatment in Patients With Lower Urinary Tract Symptoms
DC Field | Value | Language |
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dc.date.accessioned | 2022-11-24T00:41:18Z | - |
dc.date.available | 2022-11-24T00:41:18Z | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 2093-4777 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190898 | - |
dc.description.abstract | Purpose: The objective of this study was to investigate the change in near visual function after the administration of oral silodosin to patients with lower urinary tract symptoms (LUTS). Methods: This prospective study included treatment-naive patients who were scheduled to start treatment with silodosin for LUTS. A comprehensive ophthalmological evaluation including the near vision and the automated pupillometry was performed at baseline and after 3 months of silodosin treatment. For subjective assessment of near visual ability and satisfaction, a Near Activity Visual Questionnaire-10 (NAVQ-10) was also used at the same time (higher scores indicating worse quality). Results: Of 23 patients enrolled in this study, 15 continued with silodosin (8 mg once daily) treatment for 3 months and completed a follow-up evaluation. The mean age of participants was 60.4±8.4 years. Distant visual acuity and spherical error were unchanged after silodosin treatment. However, near vision acuity (logMAR) was improved after treatment (right, 0.47±0.36 vs. 0.38±0.39, P=0.018; left, 0.41±0.37 vs. 0.31±0.34, P=0.068; both, 0.27±0.26 vs. 0.21±0.27, P=0.043). Pupil size under room light decreased significantly in both eyes (right, 3.77±0.60 vs. 3.16±0.58, P=0.001; left, 3.72±0.80 vs. 3.21±0.75, P=0.002). The Rasch scale at NAVQ-10 improved from 54.7±9.9 to 48.5±11.2 (P=0.004). Conclusion: This preliminary study demonstrated that highly selective alpha-1A adrenergic receptor antagonists such as silodosin improve near visual acuity and quality in patients with LUTS/benign prostatic hyperplasia. Decrease in pupil size caused by inhibition of adrenergic alpha 1 mediated contraction of iris dilator muscle is a possible mechanism underlying improved near vision. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한배뇨장애 및 요실금학회 | - |
dc.relation.isPartOf | INTERNATIONAL NEUROUROLOGY JOURNAL(대한배뇨장애요실금학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Improvement in Near Vision Following Silodosin Treatment in Patients With Lower Urinary Tract Symptoms | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anatomy (해부학교실) | - |
dc.contributor.googleauthor | Hyun Jin Shin | - |
dc.contributor.googleauthor | Woo Suk Choi | - |
dc.contributor.googleauthor | Shin-Hyo Lee | - |
dc.contributor.googleauthor | Andrew G Lee | - |
dc.contributor.googleauthor | Aram Kim | - |
dc.contributor.googleauthor | Hyoung Keun Park | - |
dc.contributor.googleauthor | Sung Hyun Paick | - |
dc.contributor.googleauthor | Hyeong Gon Kim | - |
dc.identifier.doi | 10.5213/inj.2040274.137 | - |
dc.relation.journalcode | J01817 | - |
dc.identifier.pmid | 33504125 | - |
dc.subject.keyword | Myopia | - |
dc.subject.keyword | Presbyopia | - |
dc.subject.keyword | Pupil | - |
dc.subject.keyword | Receptors, adrenergic, alpha-1 | - |
dc.subject.keyword | Silodosin | - |
dc.citation.volume | 25 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 164 | - |
dc.citation.endPage | 171 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL NEUROUROLOGY JOURNAL, Vol.25(2) : 164-171, 2021-06 | - |
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