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Sarcopenia and Mild Cognitive Impairment in Older Adults from Six Low- and Middle-Income Countries

Authors
 Louis Jacob  ;  Karel Kostev  ;  Lee Smith  ;  Hans Oh  ;  Guillermo F López-Sánchez  ;  Jae Il Shin  ;  Adel S Abduljabbar  ;  Josep Maria Haro  ;  Ai Koyanagi 
Citation
 JOURNAL OF ALZHEIMERS DISEASE, Vol.82(4) : 1745-1754, 2021-08 
Journal Title
JOURNAL OF ALZHEIMERS DISEASE
ISSN
 1387-2877 
Issue Date
2021-08
MeSH
Africa / epidemiology ; Aged ; Asia / epidemiology ; Cognitive Dysfunction / epidemiology* ; Cross-Sectional Studies ; Developing Countries ; Female ; Global Health ; Hand Strength / physiology ; Humans ; Independent Living* ; Male ; Mexico / epidemiology ; Poverty ; Prevalence ; Sarcopenia / epidemiology*
Keywords
Community-dwelling adults ; low- and middle-income countries ; mild cognitive impairment ; multicountry study ; sarcopenia
Abstract
Background: Little is known about the relationship between sarcopenia and mild cognitive impairment (MCI) in low- and middle-income countries (LMICs).

Objective: This study aimed to investigate this association among community-dwelling adults aged≥65 years from six LMICs.

Methods: Cross-sectional, nationally representative data from the Study on Global Ageing and Adult Health (SAGE) were analyzed. These data were obtained in China, Ghana, India, Mexico, Russia, and South Africa in 2007-2010. Participants were considered to have sarcopenia if they had low skeletal muscle mass (i.e., lower skeletal mass index) and a weak handgrip strength. MCI was defined using the National Institute on Aging-Alzheimer's Association criteria. Multivariable logistic regression analysis was conducted to assess associations.

Results: The final analytical sample consisted of 12,912 individuals aged≥65 years with preservation in functional abilities without stroke (mean [standard deviation] age 72.2 [10.8] years; 45.2% males). The overall prevalence of sarcopenia and MCI were 11.3% and 18.1%, respectively. After adjusting for potential confounders, there was a positive association between sarcopenia and MCI in all countries (i.e., odds ratio [OR] > 1) with the exception of South Africa, and the overall estimate was OR = 1.60 (95% confidence interval [CI] = 1.32-1.93) with a low level of between-country heterogeneity (I2 = 0.0%).

Conclusion: There was a positive association between sarcopenia and MCI in this sample of older adults living in LMICs. Causality should be assessed in future longitudinal research, while the utility of sarcopenia as a marker of MCI should also be investigated.
Full Text
https://content.iospress.com/articles/journal-of-alzheimers-disease/jad210321
DOI
10.3233/JAD-210321
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190828
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