Cited 12 times in
Infarct Growth despite Successful Endovascular Reperfusion in Acute Ischemic Stroke: A Meta-analysis
DC Field | Value | Language |
---|---|---|
dc.date.accessioned | 2022-11-24T00:37:26Z | - |
dc.date.available | 2022-11-24T00:37:26Z | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 0195-6108 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190826 | - |
dc.description.abstract | Background: Infarct volume inversely correlates with good recovery in stroke. The magnitude and predictors of infarct growth despite successful reperfusion via endovascular treatment are not known. Purpose: We aimed to summarize the extent of infarct growth in patients with acute stroke who achieved successful reperfusion (TICI 2b-3) after endovascular treatment. Data sources: We performed a systematic review and meta-analysis by searching MEDLINE and Google Scholar for articles published up to October 31, 2020. Study selection: Studies of >10 patients reporting baseline and post-endovascular treatment infarct volumes on MR imaging were included. Only patients with TICI 2b-3 were included. We calculated infarct growth at a study level as the difference between baseline and follow-up MR imaging infarct volumes. Data analysis: Our search yielded 345 studies, and we included 10 studies reporting on 973 patients having undergone endovascular treatment who achieved successful reperfusion. Data synthesis: The mean baseline infarct volume was 19.5 mL, while the mean final infarct volume was 37.5 mL. A TICI 2b reperfusion grade was achieved in 24% of patients, and TICI 2c or 3 in 76%. The pooled mean infarct growth was 14.8 mL (95% CI, 7.9-21.7 mL). Meta-regression showed higher infarct growth in studies that reported higher baseline infarct volumes, higher rates of incomplete reperfusion (modified TICI 2b), and longer onset-to-reperfusion times. Limitations: Significant heterogeneity among studies was noted and might be driven by the difference in infarct growth between early- and late-treatment studies. Conclusions: These results suggest considerable infarct growth despite successful endovascular treatment reperfusion and call for a faster workflow and the need for specific therapies to limit infarct growth. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | American Society of Neuroradiology | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF NEURORADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Brain Ischemia* / diagnostic imaging | - |
dc.subject.MESH | Brain Ischemia* / surgery | - |
dc.subject.MESH | Endovascular Procedures* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infarction | - |
dc.subject.MESH | Ischemic Stroke* | - |
dc.subject.MESH | Reperfusion | - |
dc.subject.MESH | Stroke* / diagnostic imaging | - |
dc.subject.MESH | Stroke* / surgery | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Infarct Growth despite Successful Endovascular Reperfusion in Acute Ischemic Stroke: A Meta-analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Others | - |
dc.contributor.googleauthor | F Bala | - |
dc.contributor.googleauthor | J Ospel | - |
dc.contributor.googleauthor | B Mulpur | - |
dc.contributor.googleauthor | B J Kim | - |
dc.contributor.googleauthor | J Yoo | - |
dc.contributor.googleauthor | B K Menon | - |
dc.contributor.googleauthor | M Goyal | - |
dc.contributor.googleauthor | C Federau | - |
dc.contributor.googleauthor | S-I Sohn | - |
dc.contributor.googleauthor | M S Hussain | - |
dc.contributor.googleauthor | M A Almekhlafi | - |
dc.identifier.doi | 10.3174/ajnr.A7177 | - |
dc.relation.journalcode | J00095 | - |
dc.identifier.eissn | 1936-959X | - |
dc.identifier.pmid | 34083260 | - |
dc.identifier.url | https://www.ajnr.org/content/42/8/1472 | - |
dc.citation.volume | 42 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1472 | - |
dc.citation.endPage | 1478 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF NEURORADIOLOGY, Vol.42(8) : 1472-1478, 2021-08 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.