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Combining Cancer Vaccines with Immunotherapy: Establishing a New Immunological Approach

Authors
 Chang-Gon Kim  ;  Yun-Beom Sang  ;  Ji-Hyun Lee  ;  Hong-Jae Chon 
Citation
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.22(15) : 8035, 2021-07 
Journal Title
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN
 1661-6596 
Issue Date
2021-07
MeSH
Animals ; Antigens, Neoplasm / immunology ; Antigens, Neoplasm / therapeutic use ; Cancer Vaccines / therapeutic use* ; Humans ; Immune Checkpoint Inhibitors / therapeutic use* ; Immunotherapy* ; Neoplasms / immunology ; Neoplasms / therapy* ; Precision Medicine*
Keywords
combination immunotherapy ; immune checkpoint inhibitor ; therapeutic cancer vaccine ; tumor microenvironment
Abstract
Therapeutic cancer vaccines have become increasingly qualified for use in personalized cancer immunotherapy. A deeper understanding of tumor immunology and novel antigen delivery technologies has assisted in optimizing vaccine design. Therapeutic cancer vaccines aim to establish long-lasting immunological memory against tumor cells, thereby leading to effective tumor regression and minimizing non-specific or adverse events. However, due to several resistance mechanisms, significant challenges remain to be solved in order to achieve these goals. In this review, we describe our current understanding with respect to the use of the antigen repertoire in vaccine platform development. We also summarize various intrinsic and extrinsic resistance mechanisms behind the failure of cancer vaccine development in the past. Finally, we suggest a strategy that combines immune checkpoint inhibitors to enhance the efficacy of cancer vaccines
Files in This Item:
T202304430.pdf Download
DOI
10.3390/ijms22158035
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Gon(김창곤)
Lee, Ji Hyun(이지현)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190815
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