Cited 2 times in
Development of a bivalent conjugate vaccine candidate against rotaviral diarrhea and tuberculosis using polysaccharide from Mycobacterium tuberculosis conjugated to ΔVP8* protein from rotavirus
DC Field | Value | Language |
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dc.contributor.author | 조상래 | - |
dc.date.accessioned | 2022-11-24T00:31:47Z | - |
dc.date.available | 2022-11-24T00:31:47Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 0264-410X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190740 | - |
dc.description.abstract | Conjugation of carbohydrate antigens with a carrier protein is a clinically proven strategy to overcome the poor immunogenicity of bacterial polysaccharide. In addition to its primary role, which is to help generate a T cell-mediate long-lasting immune response directed against the carbohydrate antigen, the carrier protein in a glycoconjugate vaccine can also play an important role as a protective antigen. Among carrier proteins currently used in licensed conjugate vaccines, non-typeable Haemophilus influenzae protein D has been used as an antigenically active carrier protein. Our previous studies also indicate that some carrier proteins provide B cell epitopes, along with T cell helper epitopes. Herein we investigated the dual role of truncated rotavirus spike protein ΔVP8* as a carrier and a protective antigen. Capsular polysaccharide lipoarabinomannan (LAM), purified from Mycobacterium tuberculosis (M.tb), was chemically conjugated with ΔVP8*. Mouse immunization experiments showed that the resultant conjugates elicited strong and specific immune responses against the polysaccharide antigen, and the responses were comparable to those induced by Diphtheria toxoid (DT)-based conjugates. The conjugate vaccine induced enhanced antibody titers and functional antibodies against ΔVP8* when compared to immunization with the unconjugated ΔVP8*. Thus, these results indicate that ΔVP8* can be a relevant carrier protein for glycoconjugate vaccine and the glycoconjugates consisting of ΔVP8* with LAM are effective bivalent vaccine candidates against rotavirus and tuberculosis. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | VACCINE | - |
dc.publisher | VACCINE | - |
dc.relation.isPartOf | VACCINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antibodies, Bacterial | - |
dc.subject.MESH | Diarrhea | - |
dc.subject.MESH | Haemophilus Vaccines* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mycobacterium tuberculosis* | - |
dc.subject.MESH | Polysaccharides, Bacterial | - |
dc.subject.MESH | Rotavirus* | - |
dc.subject.MESH | Tuberculosis* / prevention & control | - |
dc.subject.MESH | Vaccines, Combined | - |
dc.subject.MESH | Vaccines, Conjugate | - |
dc.title | Development of a bivalent conjugate vaccine candidate against rotaviral diarrhea and tuberculosis using polysaccharide from Mycobacterium tuberculosis conjugated to ΔVP8* protein from rotavirus | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | Wook-Jin Park | - |
dc.contributor.googleauthor | Yeon-Kyung Yoon | - |
dc.contributor.googleauthor | Youngmi Kim | - |
dc.contributor.googleauthor | Ji-Sun Park | - |
dc.contributor.googleauthor | Ruchirkumar Pansuriya | - |
dc.contributor.googleauthor | Sang-Nae Cho | - |
dc.contributor.googleauthor | Yeong-Jae Seok | - |
dc.contributor.googleauthor | Ravi Ganapathy | - |
dc.identifier.doi | 10.1016/j.vaccine.2021.09.067 | - |
dc.contributor.localId | A03824 | - |
dc.relation.journalcode | J02776 | - |
dc.identifier.eissn | 1358-8745 | - |
dc.identifier.pmid | 34642087 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0264410X21012822 | - |
dc.subject.keyword | Carrier protein | - |
dc.subject.keyword | Conjugate vaccine | - |
dc.subject.keyword | Rotavirus | - |
dc.subject.keyword | Tuberculosis | - |
dc.subject.keyword | ΔVP8* | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.affiliatedAuthor | 조상래 | - |
dc.citation.volume | 39 | - |
dc.citation.number | 45 | - |
dc.citation.startPage | 6644 | - |
dc.citation.endPage | 6652 | - |
dc.identifier.bibliographicCitation | VACCINE, Vol.39(45) : 6644-6652, 2021-10 | - |
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