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Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state

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dc.contributor.author오지원-
dc.date.accessioned2022-10-25T00:20:59Z-
dc.date.available2022-10-25T00:20:59Z-
dc.date.issued2022-07-
dc.identifier.issn1534-5807-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/190692-
dc.description.abstractHair follicle stem cells are regulated by dermal papilla fibroblasts, their principal signaling niche. Overactivation of Hedgehog signaling in the niche dramatically accelerates hair growth and induces follicle multiplication in mice. On single-cell RNA sequencing, dermal papilla fibroblasts increase heterogeneity to include new Wnt5ahigh states. Transcriptionally, mutant fibroblasts activate regulatory networks for Gli1, Alx3, Ebf1, Hoxc8, Sox18, and Zfp239. These networks jointly upregulate secreted factors for multiple hair morphogenesis and hair-growth-related pathways. Among these is non-conventional TGF-β ligand Scube3. We show that in normal mouse skin, Scube3 is expressed only in dermal papillae of growing, but not in resting follicles. SCUBE3 protein microinjection is sufficient to induce new hair growth, and pharmacological TGF-β inhibition rescues mutant hair hyper-activation phenotype. Moreover, dermal-papilla-enriched expression of SCUBE3 and its growth-activating effect are partially conserved in human scalp hair follicles. Thus, Hedgehog regulates mesenchymal niche function in the hair follicle via SCUBE3/TGF-β mechanism.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherCell Press-
dc.relation.isPartOfDEVELOPMENTAL CELL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHCalcium-Binding Proteins / metabolism-
dc.subject.MESHCells, Cultured-
dc.subject.MESHFibroblasts / metabolism-
dc.subject.MESHHair-
dc.subject.MESHHair Follicle* / metabolism-
dc.subject.MESHHedgehog Proteins* / metabolism-
dc.subject.MESHHumans-
dc.subject.MESHMice-
dc.subject.MESHSOXF Transcription Factors / metabolism-
dc.subject.MESHTransforming Growth Factor beta / metabolism-
dc.titleHedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anatomy (해부학교실)-
dc.contributor.googleauthorYingzi Liu-
dc.contributor.googleauthorChristian F Guerrero-Juarez-
dc.contributor.googleauthorFei Xiao-
dc.contributor.googleauthorNitish Udupi Shettigar-
dc.contributor.googleauthorRaul Ramos-
dc.contributor.googleauthorChen-Hsiang Kuan-
dc.contributor.googleauthorYuh-Charn Lin-
dc.contributor.googleauthorLuis de Jesus Martinez Lomeli-
dc.contributor.googleauthorJung Min Park-
dc.contributor.googleauthorJi Won Oh-
dc.contributor.googleauthorRuiqi Liu-
dc.contributor.googleauthorSung-Jan Lin-
dc.contributor.googleauthorMarco Tartaglia-
dc.contributor.googleauthorRuey-Bing Yang-
dc.contributor.googleauthorZhengquan Yu-
dc.contributor.googleauthorQing Nie-
dc.contributor.googleauthorJi Li-
dc.contributor.googleauthorMaksim V Plikus-
dc.identifier.doi10.1016/j.devcel.2022.06.005-
dc.contributor.localIdA06327-
dc.relation.journalcodeJ00714-
dc.identifier.eissn1878-1551-
dc.identifier.pmid35777353-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1534580722004142-
dc.subject.keywordHedgehog pathway-
dc.subject.keywordLeptin receptor-
dc.subject.keywordScube3-
dc.subject.keyworddermal papilla-
dc.subject.keywordfibroblasts-
dc.subject.keywordhair follicle-
dc.subject.keywordhair growth-
dc.subject.keywordstem cell niche-
dc.contributor.alternativeNameOh, Ji Won-
dc.contributor.affiliatedAuthor오지원-
dc.citation.volume57-
dc.citation.number14-
dc.citation.startPage1758-
dc.citation.endPage1775.e7-
dc.identifier.bibliographicCitationDEVELOPMENTAL CELL, Vol.57(14) : 1758-1775.e7, 2022-07-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers

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