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Developing a Dementia Platform Databank Using Multiple Existing Cohorts

Authors
 Minwoong Kang  ;  Bo Kyoung Cheon  ;  Min Jung Hahn  ;  Sang Won Seo  ;  Juhee Cho  ;  Soo-Yong Shin  ;  Duk L Na  ;  Jaelim Cho  ;  Seong Hye Choi  ;  Danbee Kang 
Citation
 YONSEI MEDICAL JOURNAL, Vol.62(11) : 1062-1068, 2021-11 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2021-11
MeSH
Aged ; Alzheimer Disease* ; Brain ; Cognitive Dysfunction* ; Dementia* / diagnosis ; Dementia* / epidemiology ; Female ; Humans ; Pilot Projects
Keywords
Dementia ; cohort ; database ; platform
Abstract
This study was conducted as a pilot project to evaluate the feasibility of building an integrate dementia platform converging preexisting dementia cohorts from several variable levels. The following four cohorts were used to develop this pilot platform: 1) Clinical Research Center for Dementia of South Korea (CREDOS), 2) Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's disease (K-BASE), 3) Environmental Pollution-induced Neurological Effects (EPINEF) study, and 4) a prospective registry in Dementia Platform Korea project (DPKR). A total of 29916 patients were included in the platform with 348 integrated variables. Among participants, 13.9%, 31.5%, and 44.2% of patients had normal cognition, mild cognitive impairment, and dementia, respectively. The mean age was 72.4 years. Females accounted for 65.7% of all patients. Those with college or higher education and those without problems in reading or writing accounted for 12.3% and 46.8%, respectively. Marital status, cohabitation, family history of Parkinson's disease, smoking and drinking status, physical activity, sleep status, and nutrition status had rates of missing information of 50% or more. Although individual cohorts were of the same domain and of high quality, we found there were several barriers to integrating individual cohorts, including variability in study variables and measurements. Although many researchers are trying to combine pre-existing cohorts, the process of integrating past data has not been easy. Therefore, it is necessary to establish a protocol with considerations for data integration at the cohort establishment stage.
Files in This Item:
T202126193.pdf Download
DOI
10.3349/ymj.2021.62.11.1062
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Cho, Jae Lim(조재림)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190593
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