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Effects of baseline serum uric acid and apolipoprotein E4 on longitudinal cognition and cerebral metabolism

Authors
 Young-Gun Lee  ;  Mincheol Park  ;  Seong Ho Jeong  ;  Sung Woo Kang  ;  Kyoungwon Baik  ;  Jin Ho Jung  ;  Phil Hyu Lee  ;  Young Ho Sohn  ;  Byoung Seok Ye 
Citation
 NEUROBIOLOGY OF AGING, Vol.106 : 223-231, 2021-10 
Journal Title
NEUROBIOLOGY OF AGING
ISSN
 0197-4580 
Issue Date
2021-10
MeSH
Aged ; Aged, 80 and over ; Alzheimer Disease / genetics ; Alzheimer Disease / metabolism* ; Alzheimer Disease / prevention & control ; Alzheimer Disease / psychology* ; Antioxidants ; Apolipoprotein E4 / genetics* ; Brain / diagnostic imaging ; Brain / metabolism* ; Cognition* ; Cognitive Dysfunction / genetics ; Cognitive Dysfunction / metabolism ; Cognitive Dysfunction / prevention & control ; Cognitive Dysfunction / psychology ; Disease Progression ; Female ; Genotype ; Heterozygote ; Humans ; Male ; Positron-Emission Tomography ; Sex Characteristics ; Uric Acid / blood*
Keywords
Alzheimer's disease ; Apolipoprotein E4 ; Brain metabolism ; Cognition ; Serum uric acid
Abstract
Serum uric acid, a natural antioxidant, may have a protective effect on the progression of Alzheimer's disease (AD). To investigate the effect of serum uric acid on longitudinal cognitive and brain metabolic changes, we utilized data on baseline serum uric acid levels, APOE genotyping, and longitudinal cognitive scores from the Alzheimer's Disease Neuroimaging Initiative for 1,343 participants with normal cognition (NC), mild cognitive impairment (MCI), or dementia. In 979 participants, brain metabolism was measured using 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) images. Higher serum uric acid levels exhibited a detrimental effect on NC, whereas a protective trend was observed in individuals with cognitive impairment. Interestingly, higher uric acid levels were associated with a slower decline in cognitive scores and brain metabolism in females with MCI, and this effect was found in APOE4 carriers, but not in non-carriers. Longitudinal AD-like patterns of brain metabolism on FDG-PET images also appeared to mediate the effects of baseline uric acid levels on longitudinal cognitive decline. In summary, higher serum uric acid may interact with APOE4 to alleviate longitudinal metabolic changes and cognitive decline in female MCI patients.
Full Text
https://www.sciencedirect.com/science/article/pii/S0197458021001573
DOI
10.1016/j.neurobiolaging.2021.05.003
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190549
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